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CBD for the treatment of brain tumors

Recently, new study results were published in a research project at St. George's University of London in collaboration with the Dove Clinic. Dr. Julian Kenyon, dr. Wai Liu and Angus Dalleish demonstrate a reduction in the size of ependymomas, both in childhood (pediatric) and adults, through the medical use of cannabidiol. Ependymomas are defined as certain types of tumors that make up about 5 to 10% of all brain tumors (gliomas). In children, they are the third most common cancer of the central nervous system. As ependymomas of the cerebrum, they appear at any age, while in the posterior fossa they occur mainly in childhood, and in the spinal cord more in adulthood. Strong decline of tumor cellsA number of case studies of cancer patients were examined, including brain tumor patients. These were administered pharmaceutical grade quality oil based on a synthetic form of CBD. Data were collected and evaluated over four years as part of the treatment of 119 cancer patients at the Dove Clinic. In 92 percent of cases, CBD medication was seen to improve upon repeated brain scans. Either in the form of a reduction of the tumor cells that cause metastases (circulating tumor cells), or in the form of a reduction in tumor size. However, in brain tumors of adult patients who had lost their size due to CBD, the tumor continued to grow after discontinuation of cannabidiol, which then resumed treatment with the drug. According to the researchers, this study should not be entitled to comprehensive findings. It should rather be an impetus for further investigations, which are undoubtedly justified by the results. If convincing evidence is provided, pharmaceutical grade CBD oil can be made more widely available and cheaper, researchers hope. In the research on cannabis as a medicine, and on the therapeutic use of CBD in particular, there is still a lot of work to be done to understand which type of CBD oil is most effective and in which dose it can best produce the best effect , The many synergy effects with other treatment measures need to be further explored, as well as the effects of diet and lifestyle habits. Increased chances of survivalIn another study conducted by British biopharmaceutical company GW Pharmaceuticals, cannabis (1: 1) agents were administered to one group of brain tumor patients, one to another. Both were given in addition to the respective standard therapy in patients with particularly poor survival prognoses (the patients had relapsing glioblastoma multiforme, called GBM for short). While almost half of the patients in the placebo group did not survive the following year (47 percent), the drug group had a survival rate of 83 percent over the same period. On average, one patient survived the drug group for 550 days and one member of the placebo group only 369. No "do-it-yourself" medicineThe cautionary note, which I already pronounce for less severe illnesses, is all the more important in the case of cancer and similarly serious illnesses. If you have a bad illness, first of all you should consult the specialist for his diagnosis. In the case of illness, it should be refrained from experimenting on its own with any CBD oils around. The study's leaders expressly point out the differences in the qualities of various oils, so it is by no means advisable to self-medicate without consultation with the doctor. Source: GLASMANN, Dieter Klaus. CBD zur Behandlung von Hirntumoren. 1 [online]. 5 Oct, 2018]. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-zur-behandlung-von-hirntumoren/ source photo: https://pixabay.com/cs/

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What are phytocannabinoids?

Phytocannabinoids are cannabinoids produced by plants. Mainly these agents are found in cannabis plants. However, there are also indications that phytocannabinoids are also formed by other plants. Just like endocannabinoids, they activate our cannabinoid receptors. The plant genus Cannabis Sativa contains more than 100 phytocannabinoids, which belong to the group of so-called terpephenols. The best-known phytocannabinoids include THC and CBD. This group of substances has not been discovered in any other plant. Phytocannabinoids activate the CB1 and CB2 receptors of the endocannabinoid system and thereby produce their characteristic effect. The active ingredients are agonists (that is, the occupation of a receptor activates a process) or antagonists (the activation inhibits a cell process) of the CB1 or CB2 receptors. Phytocannabinoids have a high potential for use as medicine. The counterpart to this are endogenous cannabinoids. They are produced by our bodies themselves and are involved in metabolic processes and other important tasks. The two most important endocannabinoids include anandamide, 2-arachidonylglycerol (2-AG). Our endogenous cannabinoid system consists of countless receptors distributed throughout our body. CB1 receptors are mainly found in the brain, while the immune system and central nervous system are mostly CB2 receptors. It is believed that our endocannabinoid system is responsible for maintaining the balance in the body and plays an important role in our well-being. The most important phytocannabinoidsTetrahydrocannabidiol (THC)THC is probably the best-known phytocannabinoid and provides the psychoactive effect of cannabis use. This is precisely the reason why cannabis is considered illegal in many parts of the world. It can affect mood and appetite and is known for its anti-inflammatory effects. Cannabidiol (CBD)At least as well known is CBD. Cannabidiol is valued above all for its therapeutic properties, which as a dietary supplement is an ideal enrichment to the daily diet. It is not psychoactive and is legally available in many countries in the form of oils or creams. Cannabigerol (CBG)CBG is considered the precursor of most other phytocannabinoids. The cannabinoid is thought to have a variety of therapeutic uses, with studies suggesting that it is even more effective than CBD in certain conditions. Over time, enzymes from the plant convert cannabigerol into other cannabinoids, which is why the level in the "finished" plant is relatively low. Cannabidivarin (CBDV)CBDV is another non-psychoactive cannabinoid. The chemical structure is very similar to CBD and the use of cannabidivarin in the treatment of epilepsy is currently under investigation. Cannabichromene (CBC)CBC is a cannabinoid that could be of interest for its medicinal properties. Studies give an idea of ​​how CBC produces antigens in tumor cells by activating CB2 receptors that are cleared by immune cells. In addition, the use of cannabichromene in Alzheimer's therapy is discussed. Of course, these are just a small selection of the most popular phytocannabinoids. Currently, more than 100 phytocannabinoids of the cannabis plant are known, which unfold their unique effect, the entourage effect. Phytocannabinoids play an important role in our endocannabinoid system. Although some progress has already been made in research, more efforts are needed to unlock the full potential of these compounds. Source: BOEDEFELD, Christian. Was sind Phytocannabinoide? 1 [online]. 8 Nov, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-sind-phytocannabinoide/ source photo: https://pixabay.com/cs/

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