Výsledky vyhledávání pro dotaz receptor

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How does CBD work? - An overview

Cannabidiol is a versatile drug with a wide range of uses. CBD is a non-psychoactive cannabinoid. This means that it has no intoxicating effect on our central nervous system and does not affect our perception. CBD has a calming effect and can help fight inflammation, pain, cramps, anxiety, nausea and general wellbeing. Somehow or other, the effect of CBD is often described. The effect is mainly due to the activation of our cannabinoid receptors, CB1 and CB2. Today it is proven that cannabinoids have a therapeutic benefit in various diseases. Nonetheless, the question of the actual effect of CBD often crops up. How does CBD actually work? CBD is analgesicThe analgesic effect of cannabidiol has been demonstrated in numerous studies. By activating certain receptors, CBD influences pain perception. The spectrum of impact is very versatile. CBD can help with pain caused by an inflammatory condition such as arthritis. In addition, the cannabinoid is able to inhibit chronic pain, migraine or menstrual cramps. CBD is anti-inflammatoryCannabidiol can reduce acute and chronic inflammation in the body. For this reason, CBD is also often used to treat inflammation of the gastrointestinal tract, in asthma or arthritis. Also, for chronic inflammatory skin diseases such as psoriasis, the topical application of CBD may be helpful. CBD is anorexicCannabinoid CBD reduces appetite and can help you lose weight. The appetite-suppressing effect is also interesting in the context of a conscious lifestyle. This mechanism of action is due to the blockade of a specific receptor of our endocannabinoid system and is used, for example, to treat obesity. CBD is antiemeticThe effect against nausea and nausea is interesting in many ways. Not only is CBD a perfect traveling companion to help against travel sickness, it can also reduce the nausea associated with chemotherapy. As with the anorectic effect of CBD, cannabinoid receptors of our endocannabinoid system play a crucial role. CBD is anti-kineticSeveral clinical studies provide evidence for the sedative effect of CBD on the gastrointestinal tract. A disturbed digestive system can decisively affect our well-being. Not to forget that the gut plays a crucial role in our immune system and general well-being. CBD has an anxiolytic effectCBD can relieve anxiety and the symptoms it causes. CBD binds to adenosine and serotonin receptors in the spinal cord, which are activated by drugs in mental illness. Including depression and anxiety. The anxiety-calming and soothing effect can help to look at situations from a different angle and reassess them. CBD is neurolepticCBD affects the nervous system and has been shown to reduce the loss of reality, hallucinations and delusions. CBD is antiepilepticThe effective effect of epilepsy has been confirmed in some studies, many of which benefit. In conjunction with other antiepileptic therapies, seizure frequency has been reduced in patients with previously refractory epilepsy forms. CBD is antispasmodicCramping and tension can be resolved by CBD. Especially in MS-induced spasticity the cannabidiol shows a promising effect. CBD is anti-insomniacAs it turns out, the active ingredient CBD also seems to serve as a sleep aid. Many users report a significant improvement in sleep when taking CBD on a regular basis. This is not least because of the calming effect. It can make it easier to fall asleep and sleep through the night. CBD is immunosuppressiveCB2 receptors affect our immune system and are involved in a variety of functions such as immunosuppression. So far, there are only animal studies, but these show an effective effect of CBD in allergies and hypersensitivity. CBD is anti-diabeticScientists suggest that CBD could prevent diabetes and reduce consequences. Inflammation of the pancreas in type 1 diabetes affects insulin production. Due to the anti-inflammatory effect CBD can be used there. Due to its additional effect on circulatory disorders, CBD is also of interest in type 2 diabetes. CBD is neuroprotectiveA WHO report on the effects of CBD also mentions the neuroprotective effect.  ConclusionThe endoannabinoid system of the human body consists of a network of receptors that are distributed throughout our body and not infrequently, an imbalance of this system is responsible for complaints. Cannabidiol can restore homeostasis. The primary receptors CB1 and CB2 are transmitters and receivers of messenger substances and can be activated and stimulated by cannabinoids. While the CB1 receptor is responsible for controlling the nervous system, the CB2 receptor affects our immune system. The spectrum of action of CBD is huge. In any case, it should be noted that substances vary from person to person and that general statements on dosage and effects are difficult. Important is the regular intake of CBD. It is best integrated into everyday life as a dietary supplement in order to best benefit from the medical potential of cannabinoids. Source: BOEDEFELD, Christian. Wie wirkt CBD? – Eine Übersicht.28 Sep, 2019,. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/wie-wirkt-cbd-eine-uebersicht/ source photo: https://pixabay.com/cs/ 

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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CBD gegen Hautkrankheiten - nÃttzt Cannabidiol der Hautgesundheit?

CBD and skin diseases: Does cannabidiol help with atopic dermatitis?Atopic dermatitis is considered a particularly onerous skin disease, as it often occurs already in infancy. The face and scalp of the baby are already covered shortly after birth with the characteristic milk scab; on the insides of knees and elbows arise so-called flexion eczema. The scaly and weeping eczema on the skin is accompanied by tormenting itching, which robs those affected of their sleep and makes any skin contact - even wearing clothes - painful. In adults, the symptoms usually culminate in spurts, the triggers of which are often not clearly identified. Atopic dermatitis flare-ups occur when the affected immune system over-reacts to internal or external irritants. The triggers can be both specific foods and stressful situations. The idea of ​​using cannabidiol for the treatment of atopic dermatitis is obvious because the nerve fibers of the skin possess cannabinoid receptors and endocannabinoids have been shown to be involved in the regulation of the immune system. Cannabinoid ointment relieves eczema symptomsThe first attempt to treat atopic dermatitis patients with cannabinoids was undertaken by Munich scientists in 2008. They administered 2456 participants a skin cream with the cannabinoid N-palmitoylethanolamine (PEA). As a result, 60 percent of the subjects were able to reduce itching, redness, and flaking areas of the skin. More than half of the atopic dermatitis patients were also able to do without cortisone medication.  ObCBD as cannabinoid could achieve comparable effects in people with neurodermatitis, has not yet been investigated in clinical trials. Its anti-inflammatory effect, which can suppress excessive immune system responses, has been confirmed in animal studies. On the basis of previous findings, scientists call CBD and cannabidiol containing preparations as a possible future remedy for skin diseases such as eczema, but also acne, contact allergies, psoriasis and itching.  CBD for common skin diseases: Does cannabidiol have an effect on acne?To call acne a skin disease, many people consider exaggerated. In fact, statistically, around 75 to 90 percent of teenagers worldwide suffer from acne-like skin changes. In about 10 percent of those affected, however, this symptom persists in adulthood and causes physical and mental discomfort. In the process, acne does not result from unhealthy diets or poor hygiene - in fact, the pimples and pustules are the result of dysregulation of certain skin cells: both the sebaceous glands and the horn-forming cells appear overactive here. While sebum is increasingly produced, the horny cells close the exits of the sebaceous follicles. The skin fat does not drain, but offers bacteria such as the Propionibacterium acnes a breeding ground and it comes to inflammation. CBD regulates the activity of certain skin cellsAt least, laboratory tests suggest that CBD, through the activation of the type 4 vanilloid receptor, reduces both the productivity of the sebaceous cells, as well as the horn-forming activity through other mechanisms Cells (keratinocytes) inhibits. Both effects could have a positive effect on the symptoms of acne. Also in psoriasis, which is also characterized by an overactivity of the horn-forming cells, the regulative action of CBD could possibly be beneficial. However, clinical studies that would confirm a positive effect on acne or psoriasis are still missing at this time. Cannabidiol for severe skin diseasesHowever, concrete case reports on the effect of CBD on skin diseases are available elsewhere: Epidermolysis bullosa is a serious inherited skin disease that can even lead to death. Those affected suffer from painful wounds, scars and adhesions that limit the range of motion. The symptom picture is sometimes called "butterfly skin" because the epidermis of the patient seems to be as sensitive as the wing of a butterfly. Could CBD be useful here? An indication can be found in the medical literature. Here is the report of 3 epidermolysis bullosa patients who used CBD oil on the skin. All reported better wound healing, less blistering, and reduced pain from the therapy. One of the patients was even able to do without the opioid painkillers he usually took for the symptoms.  CBD on the skin - does it work in the entire organism?If you use CBD oil or cream, you should be aware that the ingredients are not only local, but also absorbed into the bloodstream. Cannabidiol even reaches the blood 10 times more effectively via the so-called transdermal passage than the psychoactive ingredient THC.  CBD oil or cream - what is best for the application on the skin?While CBD oil is dripped under the tongue, taking cannabidiol through the oral mucosa into the bloodstream, CBD cream and CBD balm develop their effect directly on the skin. Quality products are characterized by the fact that they are based on a full-spectrum extract. In addition to CBD, this contains other cannabinoids, flavonoids and terpenes, and in this way favors the so-called Entourage effect. Scientists assume that different cannabinoids increase each other's beneficial effects. High-quality CBD creams also contain no artificial preservatives, dyes and fragrances. Only vitamin E, which acts as an effective antioxidant, prevents the cream from spoiling on contact with oxygen. Natural oils and vegetable fats such as shea butter or mango butter additionally help the skin to retain its own moisture and make it supple. Source: CBD gegen Hautkrankheiten – nützt Cannabidiol der Hautgesundheit? 1 [online]. 21 Aug,2019, Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-gegen-hautkrankheiten source photo: https://pixabay.com/cs/ 

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What are phytocannabinoids?

Phytocannabinoids are cannabinoids produced by plants. Mainly these agents are found in cannabis plants. However, there are also indications that phytocannabinoids are also formed by other plants. Just like endocannabinoids, they activate our cannabinoid receptors. The plant genus Cannabis Sativa contains more than 100 phytocannabinoids, which belong to the group of so-called terpephenols. The best-known phytocannabinoids include THC and CBD. This group of substances has not been discovered in any other plant. Phytocannabinoids activate the CB1 and CB2 receptors of the endocannabinoid system and thereby produce their characteristic effect. The active ingredients are agonists (that is, the occupation of a receptor activates a process) or antagonists (the activation inhibits a cell process) of the CB1 or CB2 receptors. Phytocannabinoids have a high potential for use as medicine. The counterpart to this are endogenous cannabinoids. They are produced by our bodies themselves and are involved in metabolic processes and other important tasks. The two most important endocannabinoids include anandamide, 2-arachidonylglycerol (2-AG). Our endogenous cannabinoid system consists of countless receptors distributed throughout our body. CB1 receptors are mainly found in the brain, while the immune system and central nervous system are mostly CB2 receptors. It is believed that our endocannabinoid system is responsible for maintaining the balance in the body and plays an important role in our well-being. The most important phytocannabinoidsTetrahydrocannabidiol (THC)THC is probably the best-known phytocannabinoid and provides the psychoactive effect of cannabis use. This is precisely the reason why cannabis is considered illegal in many parts of the world. It can affect mood and appetite and is known for its anti-inflammatory effects. Cannabidiol (CBD)At least as well known is CBD. Cannabidiol is valued above all for its therapeutic properties, which as a dietary supplement is an ideal enrichment to the daily diet. It is not psychoactive and is legally available in many countries in the form of oils or creams. Cannabigerol (CBG)CBG is considered the precursor of most other phytocannabinoids. The cannabinoid is thought to have a variety of therapeutic uses, with studies suggesting that it is even more effective than CBD in certain conditions. Over time, enzymes from the plant convert cannabigerol into other cannabinoids, which is why the level in the "finished" plant is relatively low. Cannabidivarin (CBDV)CBDV is another non-psychoactive cannabinoid. The chemical structure is very similar to CBD and the use of cannabidivarin in the treatment of epilepsy is currently under investigation. Cannabichromene (CBC)CBC is a cannabinoid that could be of interest for its medicinal properties. Studies give an idea of ​​how CBC produces antigens in tumor cells by activating CB2 receptors that are cleared by immune cells. In addition, the use of cannabichromene in Alzheimer's therapy is discussed. Of course, these are just a small selection of the most popular phytocannabinoids. Currently, more than 100 phytocannabinoids of the cannabis plant are known, which unfold their unique effect, the entourage effect. Phytocannabinoids play an important role in our endocannabinoid system. Although some progress has already been made in research, more efforts are needed to unlock the full potential of these compounds. Source: BOEDEFELD, Christian. Was sind Phytocannabinoide? 1 [online]. 8 Nov, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-sind-phytocannabinoide/ source photo: https://pixabay.com/cs/

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