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What do you know about cannabinodiol?

For how many active ingredients in the cannabis plant, humanity has so far been able to really deal with only a few. Only for a few decades researchers have been researching the plant with scientific methods and trying to fathom its health-promoting properties.For a long time there were not many places in the world where cannabis research was possible from the legal situation. But gradually the individual substances of the hemp plant are examined and their pharmacological properties are scrutinized. Thus, the plant reveals more and more of its many active ingredients.More and more cannabinoids are being researched and have medical benefitsWe already know a lot about tetrahydrocannabinol (THC) and cannabidiol (CBD). And the medical benefits of the cannabinoids cannabigerol (CBG), cannabis romaine (CBC) and cannabinol (CBN), there is already some information. There are also oils especially from CBG, comparable to CBD oil, with which you can do something good for your health. But there are other cannabinoids to discover that can also be of great value to humans, such as cannabinodiol.CBND is made from cannabinolThe phytocannabinoid cannabinoidiol (CBND) is a fully flavored derivative, a variation of CBD. It is sometimes called cannabidinodiol (CBDL). In 1977, it was first isolated by Robert Lousberg. In low concentrations, CBND is found in the flowers of the female cannabis plant. It is produced as a product of the photochemical conversion of cannabinol (CBN), ie by the influence of light. Like tetrahydrocannabinol and cannabinol it has psychotropic properties.The medical benefits of CBNDCannabinodiol is only slowly becoming interesting for medicine. Therefore, little is known about the pharmacological properties of cannabinoid except that it is psychoactive in a similar manner to THC or perhaps tetrahydrocannabivarin. Meanwhile, there is increasing evidence that CBND can be used to treat neuropsychiatric disorders. The compound classified as phytocannabinoid, which is isolated from Lebanese hashish, is said to improve cognitive function in those affected. Whether cannabinodiol will play an even greater role in medical applications in the future will only have to be proven by further investigations. source: GLASMANN, Dieter Klaus. Was weiß man über Cannabinodiol?. 2019, 13 Mai,, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-weiss-man-uber-cannabinodiol/ source photo: https://pixabay.com/cs/

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Use cannabidiol for cellulite

Our skin is a big and very important organ of the body. It also partially reflects our internal health. That is why the skin is also a topic that the developers of cannabidiol-containing products are concerned about. There are now plenty of CBD creams, ointments and lotions on the market for daily care, for speeding up the healing process of minor injuries or especially for various skin diseases. Of course you can also provide your skin with the helpful cannabinoid by applying the same CBD oil that you also take orally.The health benefits of CBD oilCannabidiol is a natural and largely harmless substance derived from the cannabis plant. This is done by means of different extraction methods. The extract thus produced is added to a carrier oil, usually this is an olive or hemp seed oil. A good extract contains a complete extract of the active ingredients of the cannabis plant. Thus cannabidiol and the other cannabinoids, flavonoids and terpenes can exert all the positive effects on the endocannabinoid system and the whole body for which the plant has long been known: pain relief, reduction of depression and anxiety, protection of nerve cells and much more. In addition to the effects on the internal organs can also cure many skin complaints with CBD oils.What can CBD oil do for cellulite?Cannabidiol is an all-rounder for skin care and the treatment of skin diseases. It can be used against inflammation, itching or for wound healing. It should even support the positive course of treatment of skin cancer. The entourage effect, as the interaction of the cannabis active ingredients is called, is particularly noticeable in the application for the skin. CBD acts as an antioxidant for the skin, it binds free radicals, which promote skin aging, diseases and also cancer. For cellulite, another feature of CBD comes into play. Because it promotes blood flow in the vessels, the whole skin is better supplied with nutrients and pollutants removed.How best to use CBD for the skin?Whether you prefer to use a cannabidiol-containing care product or swears rather on the CBD oil, everyone must decide based on his experience and preferences. In general, the use of CBD oils on the skin also works very well, but this can be quite expensive when applied over a larger area of ​​skin. Therefore, the topical use of a CBD oil is particularly suitable for the treatment of small wounds or irritated skin. For general care, CBD beauty products are best. The CBD oil does not have to be set aside for that. Because applied internally, so ingested, cannabidiol works everywhere in the body, thus in the skin cells. Source: GLASMANN, Dieter Klaus Glasmann. Cannabidiol bei Cellulite einsetzen, 26 Apr, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cannabidiol-bei-cellulite-einsetzen/source photo: https://pixabay.com/cs/ 

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Can cannabinoids help in the treatment of rosacea?

Also called copper rose or fin, rosacea often occurs in adulthood. In the chronic inflammatory skin disease of the face especially the fine vessels of the cheeks, nose, forehead and chin are dilated and the skin is particularly red in these areas. Even the eyes can be affected. However, there are indications that cannabinoids and cannabis seeds can relieve the symptoms of the disease. Rosacea - explained brieflyThere are different forms of rosacea. Depending on the severity, various areas of the face are affected by the non-infectious, chronic inflammatory skin disease. Typically, especially the fine veins of the facial skin in the areas of the cheeks, nose, forehead and chin are widened and the facial areas are correspondingly reddened. Other signs may be bumpy pimples. The nose can also change as the disease progresses. Rosacea occurs in adulthood, usually between the ages of 30 and 50 years. Women are more affected than men, but the symptoms are usually more pronounced. Causes of rosaceaAbout the causes of rosacea can give no final information. Genetic factors seem to play a role in their development, since many sufferers of family members report the same symptoms. A role also seems to play the damage to the facial skin by UV rays. Solar radiation affects the connective tissue as well as blood and lymph vessels and makes a significant contribution to vascular dilation and inflammation. According to recent findings, dermatitis occurs as a result of a defective innate immune response. Factors that favor the symptoms of rosacea include stress, alcohol, sun exposure, warm drinks or spicy foods. The chronic course of the disease requires regular visits to the dermatologist. Care should be taken to avoid the above-mentioned factors that favor the disease. Typically, rosacea is treated with medication. In addition, it is extremely important to protect the affected areas from UV rays. This is where our endocannabinoid system comes into play. Among other things, the receptors of the regulatory system also occur in the skin and play a major role in the protection and regulation of our largest organ. Cannabinoids in the treatment of rosaceaBy regulating the endocannabinoid system, cannabinoids can make a significant contribution to alleviating the symptoms of rosacea. The receptors of the regulatory system also occur in the skin and can affect the growth, functionality and balance of skin cells. Scientists have been able to show [1] that cannabinoids have a positive influence on the receptors of the skin and can promote anti-inflammatory or antioxidant properties. Meanwhile, various manufacturers are offering creams and ointments enriched with cannabis or hemp plant ingredients to help treat various inflammatory skin conditions with symptoms similar to rosacea. Clinical trials and laboratory studies [2] have shown that the anti-inflammatory effects of THC and CBD can help relieve redness and irritated skin. In addition, topical application of THC has been shown to reduce symptoms of allergic inflammation. In addition to cannabinoids, hemp seed oil has promising properties that may be of interest for the treatment of rosacea symptoms. Hempseed oil contains unsaturated fatty acids, gamma-linolenic acid and oleic acid, which can reduce the inflammation of the skin. Polyunsaturated fatty acids such as omega-3 and omega-6 can promote blood circulation and provide healthy vessels. After all, stress is considered a major factor that aggravates the symptoms of rosacea. With regular use, CBD can provide more balance and well-being, which could positively affect the course of the disease. Our skin and the endocannabinoid systemScientists have observed that inflammation of the skin or other irritating stimuli strongly increases the concentration of endocannabinoids anandamide and 2-AG in the skin. It is believed that the body thereby tries to reduce pain and inflammation. In addition, it was observed that pain and inflammation could be alleviated by the suppression of enzymes that degrade endocannabinoids. Through the production of anandamide and 2-AG, our body seems to be trying to circumvent the degradation of endocannabinoids and maintain their effect longer. In addition, the two endocannabinoids influence the development of skin cells. Especially for the epidermis, the uppermost skin layer, the endocannabinoid system seems to play a role with the receptors CB1 and CB2. Source: BOEDEFELD, Christian. Können Cannabinoide bei der Behandlung von Rosazea helfen?  17 Feb, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/koennen-cannabinoide-bei-der-behandlung-von-rosazea-helfen/ source photo: https://pixabay.com/cs/

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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CBD against circulatory disorders

A number of problems an organism can develop in the course of a lifetime are associated with impaired blood flow and inadequate oxygenation of body parts and organs. These include minor cramping of the muscles in the extremities as well as stroke, in which areas of the brain are underserved and long-term brain damage can remain. Disturbed blood flowBlood flows through every part of our body, only dead cells such as hair and fingernails are not traversed by vessels that transport all imaginable nutrients to the smallest angles. Since our diet and our lifestyle also pollutants, fats and the like can enter our bloodstream, the blood flow in many parts of the body can be disturbed by deposits. In addition, with aging, the flexibility of our veins subsides, but also environmental influences and harmful habits like smoking can constrict the vessels. Small tingling and big risksRegardless of the causes of a circulatory disorder or where it is located, it is commonly referred to as ischemia (low blood flow). In the arms or legs show slight circulatory problems, in which the foot or leg begin to tingle, also cramps of the muscles are possible. The death of parts of the body, for example the well-known smoker's leg, can also be the result of a circulatory disorder. In even worse cases, ischemia threatens the heart or brain, and can lead to strokes and heart attacks, and thus become life threatening. Canes for ischemia?The fact that smoking is harmful, narrows the blood vessels and takes away their flexibility, many potheads regret, after all, it remains to this day, the most popular form of cannabis. On the other hand, the example of glaucoma, which is related to the intraocular pressure and blood flow of the eye, has long been proven that cannabis can improve hemodynamics, ie blood flow. Cannabidiol (CBD) has several effects on blood circulation. Both the soothing, relaxing effect that lowers blood pressure and the vasodilation effect may be important here. In the genesis of ischemic strokes, remarkable results have already been achieved through the use of CBD. In admittedly unsightly tests on rats, CBD has been able to minimize brain damage by 17 percent. CBD inhibits arteriosclerosisArterial calcification and deposits in the blood vessels are one of the main causes of ischemic diseases. Here cannabidiol is medically particularly interesting. Research from Switzerland now assumes that CBD can slow down the progression of arteriosclerosis caused by high blood sugar levels. This prevents ischemic diseases or influences existing ones positively. Since smoking cannabis (especially mixed with tobacco), even if it is a high CBD variety, is rather counterproductive, CBD oils and extracts, which are available as a dietary supplement, are suitable. What to look forOf course, if you suffer from a serious circulatory disorder, going to the doctor is not only compulsory but also the only sensible thing to do. The risks are too big here to carry out self-experiments. But of course you can certainly discuss the use of CBD products with the doctor. When choosing the product one should always keep in mind the entourage effect, according to which the effects of cannabinoids and terpenes favor and enhance one another. This also makes sense for ischemic symptoms, as the cannabinoid cannabigerol (CBG), for example, has an effect on blood pressure. It is therefore advisable to always use CBD products with the full spectrum of cannabis, ie full-spectrum CBD oils or full extracts. Manufacturers who work with rich raw materials and deliver quality will surely mark this on their labels. If only CBD is indicated on the packaging of an oil, and the oil may still be colorless, it can not necessarily be assumed that it contains an extract of all the active ingredients of the hemp plant. Source: KLAUS GLASMANN, Dieter. CBD gegen Durchblutungsstörungen. 1 [online], 30 Sep, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-gegen-durchblutungsstoerungen/ source photo: https://pixabay.com/cs/

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What are phytocannabinoids?

Phytocannabinoids are cannabinoids produced by plants. Mainly these agents are found in cannabis plants. However, there are also indications that phytocannabinoids are also formed by other plants. Just like endocannabinoids, they activate our cannabinoid receptors. The plant genus Cannabis Sativa contains more than 100 phytocannabinoids, which belong to the group of so-called terpephenols. The best-known phytocannabinoids include THC and CBD. This group of substances has not been discovered in any other plant. Phytocannabinoids activate the CB1 and CB2 receptors of the endocannabinoid system and thereby produce their characteristic effect. The active ingredients are agonists (that is, the occupation of a receptor activates a process) or antagonists (the activation inhibits a cell process) of the CB1 or CB2 receptors. Phytocannabinoids have a high potential for use as medicine. The counterpart to this are endogenous cannabinoids. They are produced by our bodies themselves and are involved in metabolic processes and other important tasks. The two most important endocannabinoids include anandamide, 2-arachidonylglycerol (2-AG). Our endogenous cannabinoid system consists of countless receptors distributed throughout our body. CB1 receptors are mainly found in the brain, while the immune system and central nervous system are mostly CB2 receptors. It is believed that our endocannabinoid system is responsible for maintaining the balance in the body and plays an important role in our well-being. The most important phytocannabinoidsTetrahydrocannabidiol (THC)THC is probably the best-known phytocannabinoid and provides the psychoactive effect of cannabis use. This is precisely the reason why cannabis is considered illegal in many parts of the world. It can affect mood and appetite and is known for its anti-inflammatory effects. Cannabidiol (CBD)At least as well known is CBD. Cannabidiol is valued above all for its therapeutic properties, which as a dietary supplement is an ideal enrichment to the daily diet. It is not psychoactive and is legally available in many countries in the form of oils or creams. Cannabigerol (CBG)CBG is considered the precursor of most other phytocannabinoids. The cannabinoid is thought to have a variety of therapeutic uses, with studies suggesting that it is even more effective than CBD in certain conditions. Over time, enzymes from the plant convert cannabigerol into other cannabinoids, which is why the level in the "finished" plant is relatively low. Cannabidivarin (CBDV)CBDV is another non-psychoactive cannabinoid. The chemical structure is very similar to CBD and the use of cannabidivarin in the treatment of epilepsy is currently under investigation. Cannabichromene (CBC)CBC is a cannabinoid that could be of interest for its medicinal properties. Studies give an idea of ​​how CBC produces antigens in tumor cells by activating CB2 receptors that are cleared by immune cells. In addition, the use of cannabichromene in Alzheimer's therapy is discussed. Of course, these are just a small selection of the most popular phytocannabinoids. Currently, more than 100 phytocannabinoids of the cannabis plant are known, which unfold their unique effect, the entourage effect. Phytocannabinoids play an important role in our endocannabinoid system. Although some progress has already been made in research, more efforts are needed to unlock the full potential of these compounds. Source: BOEDEFELD, Christian. Was sind Phytocannabinoide? 1 [online]. 8 Nov, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-sind-phytocannabinoide/ source photo: https://pixabay.com/cs/

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