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What do you know about cannabinodiol?

For how many active ingredients in the cannabis plant, humanity has so far been able to really deal with only a few. Only for a few decades researchers have been researching the plant with scientific methods and trying to fathom its health-promoting properties.For a long time there were not many places in the world where cannabis research was possible from the legal situation. But gradually the individual substances of the hemp plant are examined and their pharmacological properties are scrutinized. Thus, the plant reveals more and more of its many active ingredients.More and more cannabinoids are being researched and have medical benefitsWe already know a lot about tetrahydrocannabinol (THC) and cannabidiol (CBD). And the medical benefits of the cannabinoids cannabigerol (CBG), cannabis romaine (CBC) and cannabinol (CBN), there is already some information. There are also oils especially from CBG, comparable to CBD oil, with which you can do something good for your health. But there are other cannabinoids to discover that can also be of great value to humans, such as cannabinodiol.CBND is made from cannabinolThe phytocannabinoid cannabinoidiol (CBND) is a fully flavored derivative, a variation of CBD. It is sometimes called cannabidinodiol (CBDL). In 1977, it was first isolated by Robert Lousberg. In low concentrations, CBND is found in the flowers of the female cannabis plant. It is produced as a product of the photochemical conversion of cannabinol (CBN), ie by the influence of light. Like tetrahydrocannabinol and cannabinol it has psychotropic properties.The medical benefits of CBNDCannabinodiol is only slowly becoming interesting for medicine. Therefore, little is known about the pharmacological properties of cannabinoid except that it is psychoactive in a similar manner to THC or perhaps tetrahydrocannabivarin. Meanwhile, there is increasing evidence that CBND can be used to treat neuropsychiatric disorders. The compound classified as phytocannabinoid, which is isolated from Lebanese hashish, is said to improve cognitive function in those affected. Whether cannabinodiol will play an even greater role in medical applications in the future will only have to be proven by further investigations. source: GLASMANN, Dieter Klaus. Was weiß man über Cannabinodiol?. 2019, 13 Mai,, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-weiss-man-uber-cannabinodiol/ source photo: https://pixabay.com/cs/

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CBD - protective effect for the cardiovascular system

First place among the leading causes of death worldwide is cardiovascular disease, which is due to inflammation of the cardiovascular system. A good means of prevention could be the cannabinoid CBD (cannabidiol) known for its anti-inflammatory effect. Animal experiments also suggest that CBD can also help to recover better and faster from the consequences of a heart attack or stroke. Although one can counteract such diseases through a healthy lifestyle, unfortunately, most people only become aware of the dangers when the first symptoms have already appeared. Often, however, it is no longer enough to "just" get rid of bad habits, but further measures will be necessary. All by itself or in combination with conventional medical treatments, cannabis or cannabidiol could be a good way to strengthen and protect the cardiovascular system. The heart and its associated network of blood vessels, known as the cardiovascular system, acts as a body-wide transport system for our blood. If this system has an error or corruption, it can have serious consequences. On the one hand, this can trigger a heart attack, which leads to the death of one area of ​​the heart muscle (myocardium), on the other hand, a stroke can be the result, which means that the brain cells can no longer be adequately supplied. Often, such a disease can be attributed to inflammation in the organism. And this is the starting point for treatment with CBD, whose anti-inflammatory properties have been proven in various scientific studies. In one of these studies, created by an international team of researchers from Israel, Taiwan, Hungary, the USA and Switzerland, animal experiments have shown that cannabidiol can help to heal myocarditis. CD3 and CD4 lymphocyte counts decreased significantly in rats treated with CBD on a sustained basis. This could counteract an expansion of heart disease, giving the damaged tissue after a heart attack the opportunity to recover faster and more sustainably. In another study, in which rabbits were treated with CBD after a heart attack, a positive influence on the healing process could be confirmed, unlike in the placebo group. But also to prevent such a cardiovascular disease, the use of CBD may be useful to eliminate potential risk factors. In addition to the well-known sedative and stress-reducing effect, positive effects on blood pressure, metabolism and obesity could also be observed in further studies. Furthermore, American scientists have recently completed an evaluation of 24 studies conducted between 1975 and 2017 on the "link between cannabis and cardiovascular disease" and concluded that there was no clear evidence of a link between cannabis use and the triggering of heart (muscle) infarctions or strokes. In addition to the ones mentioned here, there are a lot of other studies that confirm the positive medical benefit of cannabidiol on cardiovascular disease. In addition to cannabidiol, cannabis also contains a variety of other cannabinoids. The best-known and most researched of these is probably tetrahydrocannabinol (THC). THC is often warned that it is harmful to the heart and the rest of the cardiovascular system. As so often, however, it depends on the dosage. THC, just like CBD, can activate the CB2 receptors, which are located above all in the immune cells of our body. Therefore, it also has the ability to reduce inflammation and the level of free radicals that may otherwise increase the risk of strokes or heart attacks. THC, however, also docks to the CB1 receptors in the body. These are found, inter alia, throughout the cardiovascular system, where they are everywhere from the blood vessels to the heart muscle to the nerves in the brain responsible for heart rate control. On the one hand, activation of these receptors may be positive, e.g. On the other hand, however, with high doses of THC, the interaction between the cannabinoid and the CB1 receptors may superimpose the effect of the CB2 receptors and produce the exact opposite effect. In addition, activation of the CB1 receptors may contribute to the formation of deposits of substances such as cholesterol and fat in the blood vessels. Should one therefore be faced with the decision to choose a variety that is as supportive as possible to the protection and function of the cardiovascular system, then it might be worth taking a look at the low THC / high CBD category. Source: KRONBERGER, Ferdinand. CBD – schützende Wirkung für das Herz-Kreislauf-System. 1 [online]. 19 Dec, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-schuetzende-wirkung-fuer-das-herz-kreislauf-system/ source photo: https://pixabay.com/cs/ 

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How does CBD work? - An overview

Cannabidiol is a versatile drug with a wide range of uses. CBD is a non-psychoactive cannabinoid. This means that it has no intoxicating effect on our central nervous system and does not affect our perception. CBD has a calming effect and can help fight inflammation, pain, cramps, anxiety, nausea and general wellbeing. Somehow or other, the effect of CBD is often described. The effect is mainly due to the activation of our cannabinoid receptors, CB1 and CB2. Today it is proven that cannabinoids have a therapeutic benefit in various diseases. Nonetheless, the question of the actual effect of CBD often crops up. How does CBD actually work? CBD is analgesicThe analgesic effect of cannabidiol has been demonstrated in numerous studies. By activating certain receptors, CBD influences pain perception. The spectrum of impact is very versatile. CBD can help with pain caused by an inflammatory condition such as arthritis. In addition, the cannabinoid is able to inhibit chronic pain, migraine or menstrual cramps. CBD is anti-inflammatoryCannabidiol can reduce acute and chronic inflammation in the body. For this reason, CBD is also often used to treat inflammation of the gastrointestinal tract, in asthma or arthritis. Also, for chronic inflammatory skin diseases such as psoriasis, the topical application of CBD may be helpful. CBD is anorexicCannabinoid CBD reduces appetite and can help you lose weight. The appetite-suppressing effect is also interesting in the context of a conscious lifestyle. This mechanism of action is due to the blockade of a specific receptor of our endocannabinoid system and is used, for example, to treat obesity. CBD is antiemeticThe effect against nausea and nausea is interesting in many ways. Not only is CBD a perfect traveling companion to help against travel sickness, it can also reduce the nausea associated with chemotherapy. As with the anorectic effect of CBD, cannabinoid receptors of our endocannabinoid system play a crucial role. CBD is anti-kineticSeveral clinical studies provide evidence for the sedative effect of CBD on the gastrointestinal tract. A disturbed digestive system can decisively affect our well-being. Not to forget that the gut plays a crucial role in our immune system and general well-being. CBD has an anxiolytic effectCBD can relieve anxiety and the symptoms it causes. CBD binds to adenosine and serotonin receptors in the spinal cord, which are activated by drugs in mental illness. Including depression and anxiety. The anxiety-calming and soothing effect can help to look at situations from a different angle and reassess them. CBD is neurolepticCBD affects the nervous system and has been shown to reduce the loss of reality, hallucinations and delusions. CBD is antiepilepticThe effective effect of epilepsy has been confirmed in some studies, many of which benefit. In conjunction with other antiepileptic therapies, seizure frequency has been reduced in patients with previously refractory epilepsy forms. CBD is antispasmodicCramping and tension can be resolved by CBD. Especially in MS-induced spasticity the cannabidiol shows a promising effect. CBD is anti-insomniacAs it turns out, the active ingredient CBD also seems to serve as a sleep aid. Many users report a significant improvement in sleep when taking CBD on a regular basis. This is not least because of the calming effect. It can make it easier to fall asleep and sleep through the night. CBD is immunosuppressiveCB2 receptors affect our immune system and are involved in a variety of functions such as immunosuppression. So far, there are only animal studies, but these show an effective effect of CBD in allergies and hypersensitivity. CBD is anti-diabeticScientists suggest that CBD could prevent diabetes and reduce consequences. Inflammation of the pancreas in type 1 diabetes affects insulin production. Due to the anti-inflammatory effect CBD can be used there. Due to its additional effect on circulatory disorders, CBD is also of interest in type 2 diabetes. CBD is neuroprotectiveA WHO report on the effects of CBD also mentions the neuroprotective effect.  ConclusionThe endoannabinoid system of the human body consists of a network of receptors that are distributed throughout our body and not infrequently, an imbalance of this system is responsible for complaints. Cannabidiol can restore homeostasis. The primary receptors CB1 and CB2 are transmitters and receivers of messenger substances and can be activated and stimulated by cannabinoids. While the CB1 receptor is responsible for controlling the nervous system, the CB2 receptor affects our immune system. The spectrum of action of CBD is huge. In any case, it should be noted that substances vary from person to person and that general statements on dosage and effects are difficult. Important is the regular intake of CBD. It is best integrated into everyday life as a dietary supplement in order to best benefit from the medical potential of cannabinoids. Source: BOEDEFELD, Christian. Wie wirkt CBD? – Eine Übersicht.28 Sep, 2019,. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/wie-wirkt-cbd-eine-uebersicht/ source photo: https://pixabay.com/cs/ 

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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CBD against circulatory disorders

A number of problems an organism can develop in the course of a lifetime are associated with impaired blood flow and inadequate oxygenation of body parts and organs. These include minor cramping of the muscles in the extremities as well as stroke, in which areas of the brain are underserved and long-term brain damage can remain. Disturbed blood flowBlood flows through every part of our body, only dead cells such as hair and fingernails are not traversed by vessels that transport all imaginable nutrients to the smallest angles. Since our diet and our lifestyle also pollutants, fats and the like can enter our bloodstream, the blood flow in many parts of the body can be disturbed by deposits. In addition, with aging, the flexibility of our veins subsides, but also environmental influences and harmful habits like smoking can constrict the vessels. Small tingling and big risksRegardless of the causes of a circulatory disorder or where it is located, it is commonly referred to as ischemia (low blood flow). In the arms or legs show slight circulatory problems, in which the foot or leg begin to tingle, also cramps of the muscles are possible. The death of parts of the body, for example the well-known smoker's leg, can also be the result of a circulatory disorder. In even worse cases, ischemia threatens the heart or brain, and can lead to strokes and heart attacks, and thus become life threatening. Canes for ischemia?The fact that smoking is harmful, narrows the blood vessels and takes away their flexibility, many potheads regret, after all, it remains to this day, the most popular form of cannabis. On the other hand, the example of glaucoma, which is related to the intraocular pressure and blood flow of the eye, has long been proven that cannabis can improve hemodynamics, ie blood flow. Cannabidiol (CBD) has several effects on blood circulation. Both the soothing, relaxing effect that lowers blood pressure and the vasodilation effect may be important here. In the genesis of ischemic strokes, remarkable results have already been achieved through the use of CBD. In admittedly unsightly tests on rats, CBD has been able to minimize brain damage by 17 percent. CBD inhibits arteriosclerosisArterial calcification and deposits in the blood vessels are one of the main causes of ischemic diseases. Here cannabidiol is medically particularly interesting. Research from Switzerland now assumes that CBD can slow down the progression of arteriosclerosis caused by high blood sugar levels. This prevents ischemic diseases or influences existing ones positively. Since smoking cannabis (especially mixed with tobacco), even if it is a high CBD variety, is rather counterproductive, CBD oils and extracts, which are available as a dietary supplement, are suitable. What to look forOf course, if you suffer from a serious circulatory disorder, going to the doctor is not only compulsory but also the only sensible thing to do. The risks are too big here to carry out self-experiments. But of course you can certainly discuss the use of CBD products with the doctor. When choosing the product one should always keep in mind the entourage effect, according to which the effects of cannabinoids and terpenes favor and enhance one another. This also makes sense for ischemic symptoms, as the cannabinoid cannabigerol (CBG), for example, has an effect on blood pressure. It is therefore advisable to always use CBD products with the full spectrum of cannabis, ie full-spectrum CBD oils or full extracts. Manufacturers who work with rich raw materials and deliver quality will surely mark this on their labels. If only CBD is indicated on the packaging of an oil, and the oil may still be colorless, it can not necessarily be assumed that it contains an extract of all the active ingredients of the hemp plant. Source: KLAUS GLASMANN, Dieter. CBD gegen Durchblutungsstörungen. 1 [online], 30 Sep, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-gegen-durchblutungsstoerungen/ source photo: https://pixabay.com/cs/

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CBD gegen Hautkrankheiten - nÃttzt Cannabidiol der Hautgesundheit?

CBD and skin diseases: Does cannabidiol help with atopic dermatitis?Atopic dermatitis is considered a particularly onerous skin disease, as it often occurs already in infancy. The face and scalp of the baby are already covered shortly after birth with the characteristic milk scab; on the insides of knees and elbows arise so-called flexion eczema. The scaly and weeping eczema on the skin is accompanied by tormenting itching, which robs those affected of their sleep and makes any skin contact - even wearing clothes - painful. In adults, the symptoms usually culminate in spurts, the triggers of which are often not clearly identified. Atopic dermatitis flare-ups occur when the affected immune system over-reacts to internal or external irritants. The triggers can be both specific foods and stressful situations. The idea of ​​using cannabidiol for the treatment of atopic dermatitis is obvious because the nerve fibers of the skin possess cannabinoid receptors and endocannabinoids have been shown to be involved in the regulation of the immune system. Cannabinoid ointment relieves eczema symptomsThe first attempt to treat atopic dermatitis patients with cannabinoids was undertaken by Munich scientists in 2008. They administered 2456 participants a skin cream with the cannabinoid N-palmitoylethanolamine (PEA). As a result, 60 percent of the subjects were able to reduce itching, redness, and flaking areas of the skin. More than half of the atopic dermatitis patients were also able to do without cortisone medication.  ObCBD as cannabinoid could achieve comparable effects in people with neurodermatitis, has not yet been investigated in clinical trials. Its anti-inflammatory effect, which can suppress excessive immune system responses, has been confirmed in animal studies. On the basis of previous findings, scientists call CBD and cannabidiol containing preparations as a possible future remedy for skin diseases such as eczema, but also acne, contact allergies, psoriasis and itching.  CBD for common skin diseases: Does cannabidiol have an effect on acne?To call acne a skin disease, many people consider exaggerated. In fact, statistically, around 75 to 90 percent of teenagers worldwide suffer from acne-like skin changes. In about 10 percent of those affected, however, this symptom persists in adulthood and causes physical and mental discomfort. In the process, acne does not result from unhealthy diets or poor hygiene - in fact, the pimples and pustules are the result of dysregulation of certain skin cells: both the sebaceous glands and the horn-forming cells appear overactive here. While sebum is increasingly produced, the horny cells close the exits of the sebaceous follicles. The skin fat does not drain, but offers bacteria such as the Propionibacterium acnes a breeding ground and it comes to inflammation. CBD regulates the activity of certain skin cellsAt least, laboratory tests suggest that CBD, through the activation of the type 4 vanilloid receptor, reduces both the productivity of the sebaceous cells, as well as the horn-forming activity through other mechanisms Cells (keratinocytes) inhibits. Both effects could have a positive effect on the symptoms of acne. Also in psoriasis, which is also characterized by an overactivity of the horn-forming cells, the regulative action of CBD could possibly be beneficial. However, clinical studies that would confirm a positive effect on acne or psoriasis are still missing at this time. Cannabidiol for severe skin diseasesHowever, concrete case reports on the effect of CBD on skin diseases are available elsewhere: Epidermolysis bullosa is a serious inherited skin disease that can even lead to death. Those affected suffer from painful wounds, scars and adhesions that limit the range of motion. The symptom picture is sometimes called "butterfly skin" because the epidermis of the patient seems to be as sensitive as the wing of a butterfly. Could CBD be useful here? An indication can be found in the medical literature. Here is the report of 3 epidermolysis bullosa patients who used CBD oil on the skin. All reported better wound healing, less blistering, and reduced pain from the therapy. One of the patients was even able to do without the opioid painkillers he usually took for the symptoms.  CBD on the skin - does it work in the entire organism?If you use CBD oil or cream, you should be aware that the ingredients are not only local, but also absorbed into the bloodstream. Cannabidiol even reaches the blood 10 times more effectively via the so-called transdermal passage than the psychoactive ingredient THC.  CBD oil or cream - what is best for the application on the skin?While CBD oil is dripped under the tongue, taking cannabidiol through the oral mucosa into the bloodstream, CBD cream and CBD balm develop their effect directly on the skin. Quality products are characterized by the fact that they are based on a full-spectrum extract. In addition to CBD, this contains other cannabinoids, flavonoids and terpenes, and in this way favors the so-called Entourage effect. Scientists assume that different cannabinoids increase each other's beneficial effects. High-quality CBD creams also contain no artificial preservatives, dyes and fragrances. Only vitamin E, which acts as an effective antioxidant, prevents the cream from spoiling on contact with oxygen. Natural oils and vegetable fats such as shea butter or mango butter additionally help the skin to retain its own moisture and make it supple. Source: CBD gegen Hautkrankheiten – nützt Cannabidiol der Hautgesundheit? 1 [online]. 21 Aug,2019, Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-gegen-hautkrankheiten source photo: https://pixabay.com/cs/ 

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CBD for the treatment of brain tumors

Recently, new study results were published in a research project at St. George's University of London in collaboration with the Dove Clinic. Dr. Julian Kenyon, dr. Wai Liu and Angus Dalleish demonstrate a reduction in the size of ependymomas, both in childhood (pediatric) and adults, through the medical use of cannabidiol. Ependymomas are defined as certain types of tumors that make up about 5 to 10% of all brain tumors (gliomas). In children, they are the third most common cancer of the central nervous system. As ependymomas of the cerebrum, they appear at any age, while in the posterior fossa they occur mainly in childhood, and in the spinal cord more in adulthood. Strong decline of tumor cellsA number of case studies of cancer patients were examined, including brain tumor patients. These were administered pharmaceutical grade quality oil based on a synthetic form of CBD. Data were collected and evaluated over four years as part of the treatment of 119 cancer patients at the Dove Clinic. In 92 percent of cases, CBD medication was seen to improve upon repeated brain scans. Either in the form of a reduction of the tumor cells that cause metastases (circulating tumor cells), or in the form of a reduction in tumor size. However, in brain tumors of adult patients who had lost their size due to CBD, the tumor continued to grow after discontinuation of cannabidiol, which then resumed treatment with the drug. According to the researchers, this study should not be entitled to comprehensive findings. It should rather be an impetus for further investigations, which are undoubtedly justified by the results. If convincing evidence is provided, pharmaceutical grade CBD oil can be made more widely available and cheaper, researchers hope. In the research on cannabis as a medicine, and on the therapeutic use of CBD in particular, there is still a lot of work to be done to understand which type of CBD oil is most effective and in which dose it can best produce the best effect , The many synergy effects with other treatment measures need to be further explored, as well as the effects of diet and lifestyle habits. Increased chances of survivalIn another study conducted by British biopharmaceutical company GW Pharmaceuticals, cannabis (1: 1) agents were administered to one group of brain tumor patients, one to another. Both were given in addition to the respective standard therapy in patients with particularly poor survival prognoses (the patients had relapsing glioblastoma multiforme, called GBM for short). While almost half of the patients in the placebo group did not survive the following year (47 percent), the drug group had a survival rate of 83 percent over the same period. On average, one patient survived the drug group for 550 days and one member of the placebo group only 369. No "do-it-yourself" medicineThe cautionary note, which I already pronounce for less severe illnesses, is all the more important in the case of cancer and similarly serious illnesses. If you have a bad illness, first of all you should consult the specialist for his diagnosis. In the case of illness, it should be refrained from experimenting on its own with any CBD oils around. The study's leaders expressly point out the differences in the qualities of various oils, so it is by no means advisable to self-medicate without consultation with the doctor. Source: GLASMANN, Dieter Klaus. CBD zur Behandlung von Hirntumoren. 1 [online]. 5 Oct, 2018]. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-zur-behandlung-von-hirntumoren/ source photo: https://pixabay.com/cs/

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How does CBD affect the irritable bowel?

The so-called irritable bowel syndrome (RDS) is actually no exact name of a specific disease. Rather, this term collects a number of inflammatory bowel diseases of different causes and manifestations. There are variants such as Crohn's disease, which actually go beyond the symptoms of RDS, because in Crohn's disease, the small intestine is affected, while the classic RDS occurs only in the colon. Nearly half of all cases in which a patient is referred to the gastroenterologist (gastrointestinal specialist) are related to the widespread disease. How is the irritable bowel syndrome diagnosed?Unequivocally diagnosing irritable bowel syndrome is a complicated affair. Often the symptoms can also be associated with other diseases, therefore, confusion often happen. This can often be avoided by having a good and detailed history that the doctor should really take time to do. It includes information about the period of the disease, About changes in the toilet habits and the like, which can lead the doctor on the right track. If the suspected diagnosis is in the first place, various blood tests, colonoscopy and other imaging techniques, as well as the examination of a stool sample are necessary to ensure a reliable diagnosis. How is irritable bowel syndrome treated?Since the irritable bowel is a widespread widespread disease, there are a lot of funds available, with which one can provide relief. For mild symptoms, a diet that dispenses with a range of short-chain carbohydrates and polyhydric alcohols can help. Depending on whether the condition is more likely to be constipated or diarrhea, a laxative or anti-drainage drug may be administered. In general, the increased intake of fiber is recommended. Psyllium husks and barley have proven to be particularly useful. Camomile, myrrh and coffee charcoal are also considered to be very effective in relieving symptoms. To restore a healthy intestinal flora, the use of so-called probiotics (bacterial strains) was helpful. Although the pharmaceutical industry has also developed some products for the treatment of irritable bowel syndrome, these are often associated with side effects that do not justify their use for many people. The natural alternatives are clearly to be preferred here. What Can CBD Do For Irritable Bowel Syndrome?In 2004, the neurologist and former president of the International Association for Cannabis as Medicine, Ethan Russo, linked irritable bowel syndrome to the endocannabinoid system or deficits in a publication. Russo points to studies showing that malfunctions in the endocannabinoid system can cause inflammatory bowel disease. Consequently, cannabis can effectively remedy this situation. At first, it was claimed that cannabidiol (CBD) alone was not enough, but THC was also needed. This claim has since been revised, and it has been found that CBD is an important agent in the treatment of inflammatory bowel disease, which can both fight inflammation and regulate the function of glial cells (cells in the nervous tissue, but which are not neurons) , The immunomodulatory properties of CBD have been shown to positively affect disease progression and symptoms in studies. CBD can be of great help even in the severe Crohn's disease, and most recent research has yielded very promising results, making CBD a real hope for many gastrointestinal patients. Source: GLASMANN, Dieter Klaus. Wie wirkt CBD auf den Reizdarm?, 3 Oct, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/wie-wirkt-cbd-auf-den-reizdarm/ source photo: https://pixabay.com/cs/

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Is CBD suitable for children?

Cannabis contains many pharmacologically interesting properties, which are primarily responsible for two groups of substances, cannabinoids and terpenes. Among the cannabinoids, Δ9-trans-tetrahydrocannabinol, THC for short, has been of particular interest over the last decades, especially in the area of ​​consumption. Only a few years ago, a second cannabinoid has been recognized by science and the public, making it the most interesting agent of hemp for many people today, especially for those who do not want it intoxicating. Of course we are talking about cannabidiol (CBD), a molecular compound that can have a lot of medicinal functions without the psychoactive effects that THC has. Cannabidiol is harmless and healthy at the same timeSince CBD has proven to be very useful and harmless, legal cannabinoid has made it into a variety of health-promoting agents for external and internal use. Whether for consumption in food or dietary supplements, or even applied to the skin by ointments, tinctures or creams, CBD has become the trend of the health and wellness industry. In addition, it remains interesting for medical research and practice. Epilepsy, sleep disorders, anxiety disorders, ADHD and many other diseases can be treated successfully with cannabidiol. The contradictory treatment of CBDSome of the conditions for which CBD promises relief, such as epilepsy and ADHD, affect children in particular. Entering specialty stores whose product ranges are CBD cannabis products, however, may generally be entered only from the age of 18 years. Thus, it is quite understandable that some people are unsure about whether CBD can cause harm to children. If it is not psychoactive and harmless, can it then be administered to a child on a private basis, so that it also benefits from the health benefits? Do you have to hide your CBD products from your children, or can you keep them accessible to them? How compatible is the safety of cannabidiol with the age restrictions that CBD shops are subject to? Cannabidiol in public and legal perceptionTo understand these circumstances, one has to take a closer look at several factors. The legal situation that exists for CBD is due to the fact that cannabidiol is still an active ingredient derived from cannabis. This and the THC content which is often present in CBD products, even if in very low concentrations, justify the age restrictions for CBD shops. Of course, the fact that they mostly sell smokers and smokers in addition to CBD oils and Co. is also a good reason not to let minors into the shops. Thus, the legal position for CBD could change in parts insofar as an assortment includes only products with no THC content and no goods associated with smoking or other non-intoxicating cannabis applications. Health food stores or pharmacies offering hemp products are not subject to such age restrictions. It is therefore also a question of the milieu, with which the CBD products surround themselves, whether they are perceived as health-promoting or as questionable. Safety of CBD is confirmed by WHOAfter intensive research into the substance, the World Health Organization WHO has declared Cannabidiol safe to use. No adverse health effects or risks associated with the use of CBD could be identified during the studies carried out by the WHO itself. This means in plain language that you could not prove any side effects or the like. This makes CBD safer than most drugs that are available in the pharmacy over the counter. So who would give his child an ibuprofen in pain or aspirin, which should also be able to safely administer CBD, if the child has a condition that can be positively influenced by CBD. Is CBD suitable for children only as a remedy or as a nutritional supplement?The fact that CBD can help children suffering from epilepsy, for example, or other serious ailments has been proven by numerous studies and is now also relatively well-known through reports that have become public. However, many people may believe that they need to keep their CBD products away from their children. This is not the case, because CBD is also excellent for children for general health promotion. For example, if children are sleeping badly, or are suffering from anxiety, or are generally tormented by restlessness, cannabidiol can help them relax and sleep well. Even in children diagnosed with ADHD, CBD can be used effectively to prevent treatment with Ritalin. CBD can easily be integrated into a child's everyday life without the impression of medication. Many of the very natural products can be used to prepare drinks and food. Source: GLASMANN, Dieter Klaus. Ist CBD für Kinder geeignet? 1 [online] Dec, 2018, Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/ist-cbd-fuer-kinder-geeignet/ source photo: https://pixabay.com/cs/folder_openPřiřazené štítky

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What is Cannabis Drug (CBC)?

Cannabis Cirrus (CBC) is one of over 100 cannabinoids. Although the phytocannabinoid itself has no analgesic effect, it is believed to play an important role in relieving pain and inflammation. Besides CBD and THC, cannabis is a less well-known cannabinoid. CBC is not psychoactive and it is believed that it can significantly enhance the effects of other cannabinoids. Thus, it could play an important role in the entourage effect. In 1966, science first became aware of CBC. Although the drug is not receiving much attention, the potential of CBC is quite promising. Researchers believe it plays a key role in the anti-inflammatory and analgesic effects of CBD and THC, and that CBCA is formed from the acid. How does CBC work?Like all other cannabinoids, CBC interacts with the CB1 and CB2 receptors of our endocannabinoid system. In addition, cannabis bromide also affects the receptors TRPA1 and TRPV1. These channels play a central role in signal transmission and the sensation of pain. CBC is considered to be one of the most abundant cannabinoids and is the third most common phytocannabinoid after THC and CBD - a strong argument for more intensive research into its potential. The meaning of CBCIn cannabis, the combined effect of individual cannabinoids, also referred to as the entourage effect, plays a crucial role. This means that cannabis chromosomes can make an important contribution to the effects of THC or CBD as well as other compounds. This is also the reason why patients with full-spectrum extracts have the best experience. It's not that there's no data on the medical potential of cannabis chromosomes at all. In 2016, the Journal for Experimental Dermatology published a study ) examining the efficacy of CBC and other non-psychoactive cannabinoids in the treatment of acne and other skin problems , The data collected suggest that CBC, CBDV and THCV may inhibit the onset of acne. In addition, all cannabinoids showed a promising anti-inflammatory effect. CBC In the 1970s, it was found that CBC was found mainly in Indian landrace varieties. By crossing and creating new varieties with a high THC content and altered genetic make-up, it may now be difficult to find plants of comparable value to those of the past. Analysis results of medical strains such as Bedrocan, which is issued in German pharmacies, show how small the proportion of CBC is still. In the case of Bedrocan, the analysis shows a level of 0.01-0.12% CBD. Source: BOEDEFELD, Christian. Was ist Cannabichromen (CBC)? 1 [online], 13 Nov, 2018 Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-ist-cannabichromen-cbc/ source photo: https://pixabay.com/cs/  

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