Výsledky vyhledávání pro dotaz irritable

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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How does CBD affect the irritable bowel?

The so-called irritable bowel syndrome (RDS) is actually no exact name of a specific disease. Rather, this term collects a number of inflammatory bowel diseases of different causes and manifestations. There are variants such as Crohn's disease, which actually go beyond the symptoms of RDS, because in Crohn's disease, the small intestine is affected, while the classic RDS occurs only in the colon. Nearly half of all cases in which a patient is referred to the gastroenterologist (gastrointestinal specialist) are related to the widespread disease. How is the irritable bowel syndrome diagnosed?Unequivocally diagnosing irritable bowel syndrome is a complicated affair. Often the symptoms can also be associated with other diseases, therefore, confusion often happen. This can often be avoided by having a good and detailed history that the doctor should really take time to do. It includes information about the period of the disease, About changes in the toilet habits and the like, which can lead the doctor on the right track. If the suspected diagnosis is in the first place, various blood tests, colonoscopy and other imaging techniques, as well as the examination of a stool sample are necessary to ensure a reliable diagnosis. How is irritable bowel syndrome treated?Since the irritable bowel is a widespread widespread disease, there are a lot of funds available, with which one can provide relief. For mild symptoms, a diet that dispenses with a range of short-chain carbohydrates and polyhydric alcohols can help. Depending on whether the condition is more likely to be constipated or diarrhea, a laxative or anti-drainage drug may be administered. In general, the increased intake of fiber is recommended. Psyllium husks and barley have proven to be particularly useful. Camomile, myrrh and coffee charcoal are also considered to be very effective in relieving symptoms. To restore a healthy intestinal flora, the use of so-called probiotics (bacterial strains) was helpful. Although the pharmaceutical industry has also developed some products for the treatment of irritable bowel syndrome, these are often associated with side effects that do not justify their use for many people. The natural alternatives are clearly to be preferred here. What Can CBD Do For Irritable Bowel Syndrome?In 2004, the neurologist and former president of the International Association for Cannabis as Medicine, Ethan Russo, linked irritable bowel syndrome to the endocannabinoid system or deficits in a publication. Russo points to studies showing that malfunctions in the endocannabinoid system can cause inflammatory bowel disease. Consequently, cannabis can effectively remedy this situation. At first, it was claimed that cannabidiol (CBD) alone was not enough, but THC was also needed. This claim has since been revised, and it has been found that CBD is an important agent in the treatment of inflammatory bowel disease, which can both fight inflammation and regulate the function of glial cells (cells in the nervous tissue, but which are not neurons) , The immunomodulatory properties of CBD have been shown to positively affect disease progression and symptoms in studies. CBD can be of great help even in the severe Crohn's disease, and most recent research has yielded very promising results, making CBD a real hope for many gastrointestinal patients. Source: GLASMANN, Dieter Klaus. Wie wirkt CBD auf den Reizdarm?, 3 Oct, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/wie-wirkt-cbd-auf-den-reizdarm/ source photo: https://pixabay.com/cs/

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