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What do you know about cannabinodiol?

For how many active ingredients in the cannabis plant, humanity has so far been able to really deal with only a few. Only for a few decades researchers have been researching the plant with scientific methods and trying to fathom its health-promoting properties.For a long time there were not many places in the world where cannabis research was possible from the legal situation. But gradually the individual substances of the hemp plant are examined and their pharmacological properties are scrutinized. Thus, the plant reveals more and more of its many active ingredients.More and more cannabinoids are being researched and have medical benefitsWe already know a lot about tetrahydrocannabinol (THC) and cannabidiol (CBD). And the medical benefits of the cannabinoids cannabigerol (CBG), cannabis romaine (CBC) and cannabinol (CBN), there is already some information. There are also oils especially from CBG, comparable to CBD oil, with which you can do something good for your health. But there are other cannabinoids to discover that can also be of great value to humans, such as cannabinodiol.CBND is made from cannabinolThe phytocannabinoid cannabinoidiol (CBND) is a fully flavored derivative, a variation of CBD. It is sometimes called cannabidinodiol (CBDL). In 1977, it was first isolated by Robert Lousberg. In low concentrations, CBND is found in the flowers of the female cannabis plant. It is produced as a product of the photochemical conversion of cannabinol (CBN), ie by the influence of light. Like tetrahydrocannabinol and cannabinol it has psychotropic properties.The medical benefits of CBNDCannabinodiol is only slowly becoming interesting for medicine. Therefore, little is known about the pharmacological properties of cannabinoid except that it is psychoactive in a similar manner to THC or perhaps tetrahydrocannabivarin. Meanwhile, there is increasing evidence that CBND can be used to treat neuropsychiatric disorders. The compound classified as phytocannabinoid, which is isolated from Lebanese hashish, is said to improve cognitive function in those affected. Whether cannabinodiol will play an even greater role in medical applications in the future will only have to be proven by further investigations. source: GLASMANN, Dieter Klaus. Was weiß man über Cannabinodiol?. 2019, 13 Mai,, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-weiss-man-uber-cannabinodiol/ source photo: https://pixabay.com/cs/

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Use cannabidiol for cellulite

Our skin is a big and very important organ of the body. It also partially reflects our internal health. That is why the skin is also a topic that the developers of cannabidiol-containing products are concerned about. There are now plenty of CBD creams, ointments and lotions on the market for daily care, for speeding up the healing process of minor injuries or especially for various skin diseases. Of course you can also provide your skin with the helpful cannabinoid by applying the same CBD oil that you also take orally.The health benefits of CBD oilCannabidiol is a natural and largely harmless substance derived from the cannabis plant. This is done by means of different extraction methods. The extract thus produced is added to a carrier oil, usually this is an olive or hemp seed oil. A good extract contains a complete extract of the active ingredients of the cannabis plant. Thus cannabidiol and the other cannabinoids, flavonoids and terpenes can exert all the positive effects on the endocannabinoid system and the whole body for which the plant has long been known: pain relief, reduction of depression and anxiety, protection of nerve cells and much more. In addition to the effects on the internal organs can also cure many skin complaints with CBD oils.What can CBD oil do for cellulite?Cannabidiol is an all-rounder for skin care and the treatment of skin diseases. It can be used against inflammation, itching or for wound healing. It should even support the positive course of treatment of skin cancer. The entourage effect, as the interaction of the cannabis active ingredients is called, is particularly noticeable in the application for the skin. CBD acts as an antioxidant for the skin, it binds free radicals, which promote skin aging, diseases and also cancer. For cellulite, another feature of CBD comes into play. Because it promotes blood flow in the vessels, the whole skin is better supplied with nutrients and pollutants removed.How best to use CBD for the skin?Whether you prefer to use a cannabidiol-containing care product or swears rather on the CBD oil, everyone must decide based on his experience and preferences. In general, the use of CBD oils on the skin also works very well, but this can be quite expensive when applied over a larger area of ​​skin. Therefore, the topical use of a CBD oil is particularly suitable for the treatment of small wounds or irritated skin. For general care, CBD beauty products are best. The CBD oil does not have to be set aside for that. Because applied internally, so ingested, cannabidiol works everywhere in the body, thus in the skin cells. Source: GLASMANN, Dieter Klaus Glasmann. Cannabidiol bei Cellulite einsetzen, 26 Apr, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cannabidiol-bei-cellulite-einsetzen/source photo: https://pixabay.com/cs/ 

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The anti-oxidative properties of CBD

Many nutrition experts and counselors point out how important antioxidants are to our health and well-being. But what exactly is behind these substances? What qualities do they possess and how can our bodies benefit from them? Simply put, antioxidants are substances that inhibit oxidation and reduce the associated so-called oxidative stress. During oxidation, waste products are formed in our body and free radicals are formed. The body's own antioxidants, such as glutathione, are usually insufficient to prevent the production of free radicals. This is especially the case with increasing age, as the oxidative stress increases with increasing age. That is why it is important to supply the body with antioxidants from the diet. Actually, oxygen is associated with life. That's true, of course, but in this case our body produces the already mentioned free radicals by oxidation of other substances (reaction with oxygen). From them, a kind of chain reaction can occur in which molecules, cells or tissue can be damaged or irreparably destroyed. By reacting with them, antioxidants protect against free radicals. CBD as an antioxidantFor a long time, vitamins such as C and E were among the most powerful antioxidants. In terms of mode of action, cannabidiol does not really differ from an antioxidant. The chemical structure of the cannabinoid contains an oxygen atom that can be released to free radicals and thus neutralizes them. This free oxygen compound is responsible for the antioxidant effects of CBD. Several studies even confirm that the cannabinoids THC and CBD have a significant neuroprotective effect as antioxidants, which is many times stronger than for vitamins C and E. ConclusionAntioxidants are extremely important to our body. Without them, free radicals can cause immense damage. By providing oxygen atoms, antioxidants can neutralize the harmful compounds, making a vital contribution to our health. In addition to vitamins C and E, cannabidiol has become a good source of antioxidants. Although more research is needed in this area, the results obtained to date are quite promising and provide insight into the antioxidant potential of CBD. In addition, CBD could also keep neurodegenerative diseases such as Parkinson's or Alzheimer's at bay. The potential of cannabinoid is huge. Unfortunately, it is difficult to make general statements and the effectiveness of CBD is best tested by yourself. Every organism responds differently and should be slowly accustomed to using CBD as a nutritional supplement. Although no serious side effects of CBD are known, consult a doctor if you have any concerns about taking it. Source: BOEDEFELD, Christian. Die antodioxidativen Eigenschaften von CBD. 1 [online].19 Dec, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/die-antodioxidativen-eigenschaften-von-cbd/ source photo: https://pixabay.com/cs/  

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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CBD Oil - What can the miracle cure?

CBD oil is the abbreviation for cannabidiol oil. This is a hemp extract oil - without intoxicating effect. However, you can use the oil to relieve health problems. Because the hemp extract oil has an analgesic effect and balances the moods of the psyche. Hemp extract is obtained from the hemp flower. These plants hardly contain tetrahydrocannabinol (THC) because CBD oil must not contain THC. Otherwise it is under the Narcotics Act. Therefore, CBD oil is made from hemp plants that contain a lot of cannabidiol. The compositionBy adding a base oil, hemp extract oil also contains hempseed oil. Cannabidiol, flavonoids and more than 50 substances of cannabinoids are detectable in the hemp extract. It contains no substances that are responsible for a noise effect. Relieve discomfortYou can use CBD oil to relieve many ailments. Unfortunately, we can not make any medically relevant promises in connection with CBD because of the current legal situation.As there are always new positive news from medicine and research and a number of studies indicate the positive effects, you can find many interesting articles on the net.The application CBD oil can be used both externally and internally. Please always follow the recommendation of the manufacturer, if you intend to take the oil internally. So the drops are given in the morning and evening under the tongue. From experience, it makes sense to start with a small amount first. So you can watch how you get the drops. Then you can increase the amount slowly. The exact number of drops depends on the compatibility. Therefore, you should always find out for yourself which dose helps you. side effectsIn general, CBD oil is well tolerated. Nevertheless, it is possible that you notice side effects. It can be fatigue, nausea or diarrhea. Where the signs such as more or less hungry are not clearly attributable to the drop. These effects also change the weight. You should ask a doctor if you can use the oil if you regularly take other medicines. Because even here, the effect of the drugs can be influenced. If you use the oil to rub the skin with it, then you can do a test before. If there is no change in the treated area then you can apply the oil. Since there are not enough studies with the oil, pregnant women and children should not use CBD oil. This also applies to the intake of the drops, because it is not known exactly how the oil in children affects the development and health. ConclusionYou can relieve or alleviate many health problems with CBD oil. If you want to buy the drops, then look for a good quality and best without THC. The drops are not prescription. You can buy the product yourself. You take no drugs with CBD Oil and you will not get intoxicated if you use CBD Oil. So you can not depend on the drops. Serious side effects are not known, however, a slight intolerance may occur. Taking hemp as a remedy is not new. The positive effect has been known for a long time. CBD oil is a real wonder drug. In many cases the effect has been proven in studies. The research is still not so far that there is the product as a drug. Source: CBD Öl - Was kann das Wundermittel? 12 Jul, 2018. Dostupné z: https://www.mrs-hanf.de/2018/07/12/cbd-%C3%B6l-was-kann-das-wundermittel/ source photo: https://pixabay.com/cs/

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CBD as antibiotic - does cannabidiol help against bacterial infections?

inflammation or respiratory tract infection - almost every patient had to take antibiotics once in a lifetime to get rid of the condition. However, with growing coverage of resistant bacteria, fewer and fewer people trust the chemical drugs without reservation; many are looking for alternatives. If natural products such as e.g. CBD oil actually help here? What causes an antibiotic?The term antibiotics is composed of the Greek terms "anti" and "bios" and means something like: against life. Originally it referred to as bacteria-expelled metabolites that inhibit the growth of other microorganisms in their environment. In modern medicine, all partially and fully synthetic substances that kill bacteria and inhibit their multiplication as an antibiotic apply. Problems with antibiotics - do natural ingredients have benefits?The biggest problem with using synthetic antibiotics is that certain strains of bacteria become insensitive to them over time and a drug loses its effect. Not only the frequent prescription of antibiotics promotes the resistance, but also their industrial use. In the animal fattening producers want to prevent infectious diseases by large-scale Antibiotikagaben, but thereby risk residues in their products. These in turn can lead to the formation of resistant bacterial strains in the consumer. Researchers are increasingly testing natural antibacterial substances such as oregano oil, garlic extracts or honey as part of their search for drug candidates for resistant bacteria. Here is the thesis that natural substances are too complex for bacteria to resist. In the course of this, CBD will also be interesting for research: Does CBD have antibiotic properties?Researchers already demonstrated that cannabidiol has an antibacterial effect on streptococci and staphylococci in the 1970s. [1] At that time it was concluded from the results that this effect applies only to gram-positive bacteria, whereas gram-negative bacteria are resistant to CBD. Other data was presented by the research team led by Mark Blaskovich at this year's American Society for Microbiology conference, ASM Microbe in San Francisco. According to Blaskovich, the previously unpublished study shows how CBD eliminated bacterial strains that are already resistant to common antibiotics. In addition, no resistance to cannabidiol developed in the bacteria even after exposure to the cannabinoid for about 20 days. According to the scientists, CBD demonstrated efficacy against MRSA, the methicillin-resistant Staphylococcus aureus, which is responsible for serious hospital infections. Lead chemist Mark Blaskovich, in an interview with Newsweek, explained the current state of knowledge on CBD as an antibiotic: "We do not yet know how it works, but it could have a unique mechanism if confirmed to work against antibiotic-resistant bacteria." Can CBD increase the effects of antibiotics?In a study published in 2019, researchers demonstrated in a study published in 2019 how CBD could influence resistant bacteria: experts call materials that release bacteria via their outer sheath as outer membrane vesicles. They primarily serve the communication of the bacteria with each other, but also the exchange of DNA, the formation of a biofilm and the release of defense enzymes against immune cells. Cannabidiol can effectively inhibit these membrane vesicles, particularly in the bacterium E. coli. As a result, various antibiotics in combination with CBD were more effective against certain Gram-negative bacteria. According to the authors, CBD may help reduce resistance to antibiotics.  Source: CBD als Antibiotikum – hilft Cannabidiol gegen bakterielle Infektionen? 1 [online]. 23 Oct, 2018. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-als-antibiotikum source photo: https://pixabay.com/cs/

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Is CBD suitable for children?

Cannabis contains many pharmacologically interesting properties, which are primarily responsible for two groups of substances, cannabinoids and terpenes. Among the cannabinoids, Δ9-trans-tetrahydrocannabinol, THC for short, has been of particular interest over the last decades, especially in the area of ​​consumption. Only a few years ago, a second cannabinoid has been recognized by science and the public, making it the most interesting agent of hemp for many people today, especially for those who do not want it intoxicating. Of course we are talking about cannabidiol (CBD), a molecular compound that can have a lot of medicinal functions without the psychoactive effects that THC has. Cannabidiol is harmless and healthy at the same timeSince CBD has proven to be very useful and harmless, legal cannabinoid has made it into a variety of health-promoting agents for external and internal use. Whether for consumption in food or dietary supplements, or even applied to the skin by ointments, tinctures or creams, CBD has become the trend of the health and wellness industry. In addition, it remains interesting for medical research and practice. Epilepsy, sleep disorders, anxiety disorders, ADHD and many other diseases can be treated successfully with cannabidiol. The contradictory treatment of CBDSome of the conditions for which CBD promises relief, such as epilepsy and ADHD, affect children in particular. Entering specialty stores whose product ranges are CBD cannabis products, however, may generally be entered only from the age of 18 years. Thus, it is quite understandable that some people are unsure about whether CBD can cause harm to children. If it is not psychoactive and harmless, can it then be administered to a child on a private basis, so that it also benefits from the health benefits? Do you have to hide your CBD products from your children, or can you keep them accessible to them? How compatible is the safety of cannabidiol with the age restrictions that CBD shops are subject to? Cannabidiol in public and legal perceptionTo understand these circumstances, one has to take a closer look at several factors. The legal situation that exists for CBD is due to the fact that cannabidiol is still an active ingredient derived from cannabis. This and the THC content which is often present in CBD products, even if in very low concentrations, justify the age restrictions for CBD shops. Of course, the fact that they mostly sell smokers and smokers in addition to CBD oils and Co. is also a good reason not to let minors into the shops. Thus, the legal position for CBD could change in parts insofar as an assortment includes only products with no THC content and no goods associated with smoking or other non-intoxicating cannabis applications. Health food stores or pharmacies offering hemp products are not subject to such age restrictions. It is therefore also a question of the milieu, with which the CBD products surround themselves, whether they are perceived as health-promoting or as questionable. Safety of CBD is confirmed by WHOAfter intensive research into the substance, the World Health Organization WHO has declared Cannabidiol safe to use. No adverse health effects or risks associated with the use of CBD could be identified during the studies carried out by the WHO itself. This means in plain language that you could not prove any side effects or the like. This makes CBD safer than most drugs that are available in the pharmacy over the counter. So who would give his child an ibuprofen in pain or aspirin, which should also be able to safely administer CBD, if the child has a condition that can be positively influenced by CBD. Is CBD suitable for children only as a remedy or as a nutritional supplement?The fact that CBD can help children suffering from epilepsy, for example, or other serious ailments has been proven by numerous studies and is now also relatively well-known through reports that have become public. However, many people may believe that they need to keep their CBD products away from their children. This is not the case, because CBD is also excellent for children for general health promotion. For example, if children are sleeping badly, or are suffering from anxiety, or are generally tormented by restlessness, cannabidiol can help them relax and sleep well. Even in children diagnosed with ADHD, CBD can be used effectively to prevent treatment with Ritalin. CBD can easily be integrated into a child's everyday life without the impression of medication. Many of the very natural products can be used to prepare drinks and food. Source: GLASMANN, Dieter Klaus. Ist CBD für Kinder geeignet? 1 [online] Dec, 2018, Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/ist-cbd-fuer-kinder-geeignet/ source photo: https://pixabay.com/cs/folder_openPřiřazené štítky

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