Výsledky vyhledávání pro dotaz crohn disease

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Can cannabinoids help in the treatment of rosacea?

Also called copper rose or fin, rosacea often occurs in adulthood. In the chronic inflammatory skin disease of the face especially the fine vessels of the cheeks, nose, forehead and chin are dilated and the skin is particularly red in these areas. Even the eyes can be affected. However, there are indications that cannabinoids and cannabis seeds can relieve the symptoms of the disease. Rosacea - explained brieflyThere are different forms of rosacea. Depending on the severity, various areas of the face are affected by the non-infectious, chronic inflammatory skin disease. Typically, especially the fine veins of the facial skin in the areas of the cheeks, nose, forehead and chin are widened and the facial areas are correspondingly reddened. Other signs may be bumpy pimples. The nose can also change as the disease progresses. Rosacea occurs in adulthood, usually between the ages of 30 and 50 years. Women are more affected than men, but the symptoms are usually more pronounced. Causes of rosaceaAbout the causes of rosacea can give no final information. Genetic factors seem to play a role in their development, since many sufferers of family members report the same symptoms. A role also seems to play the damage to the facial skin by UV rays. Solar radiation affects the connective tissue as well as blood and lymph vessels and makes a significant contribution to vascular dilation and inflammation. According to recent findings, dermatitis occurs as a result of a defective innate immune response. Factors that favor the symptoms of rosacea include stress, alcohol, sun exposure, warm drinks or spicy foods. The chronic course of the disease requires regular visits to the dermatologist. Care should be taken to avoid the above-mentioned factors that favor the disease. Typically, rosacea is treated with medication. In addition, it is extremely important to protect the affected areas from UV rays. This is where our endocannabinoid system comes into play. Among other things, the receptors of the regulatory system also occur in the skin and play a major role in the protection and regulation of our largest organ. Cannabinoids in the treatment of rosaceaBy regulating the endocannabinoid system, cannabinoids can make a significant contribution to alleviating the symptoms of rosacea. The receptors of the regulatory system also occur in the skin and can affect the growth, functionality and balance of skin cells. Scientists have been able to show [1] that cannabinoids have a positive influence on the receptors of the skin and can promote anti-inflammatory or antioxidant properties. Meanwhile, various manufacturers are offering creams and ointments enriched with cannabis or hemp plant ingredients to help treat various inflammatory skin conditions with symptoms similar to rosacea. Clinical trials and laboratory studies [2] have shown that the anti-inflammatory effects of THC and CBD can help relieve redness and irritated skin. In addition, topical application of THC has been shown to reduce symptoms of allergic inflammation. In addition to cannabinoids, hemp seed oil has promising properties that may be of interest for the treatment of rosacea symptoms. Hempseed oil contains unsaturated fatty acids, gamma-linolenic acid and oleic acid, which can reduce the inflammation of the skin. Polyunsaturated fatty acids such as omega-3 and omega-6 can promote blood circulation and provide healthy vessels. After all, stress is considered a major factor that aggravates the symptoms of rosacea. With regular use, CBD can provide more balance and well-being, which could positively affect the course of the disease. Our skin and the endocannabinoid systemScientists have observed that inflammation of the skin or other irritating stimuli strongly increases the concentration of endocannabinoids anandamide and 2-AG in the skin. It is believed that the body thereby tries to reduce pain and inflammation. In addition, it was observed that pain and inflammation could be alleviated by the suppression of enzymes that degrade endocannabinoids. Through the production of anandamide and 2-AG, our body seems to be trying to circumvent the degradation of endocannabinoids and maintain their effect longer. In addition, the two endocannabinoids influence the development of skin cells. Especially for the epidermis, the uppermost skin layer, the endocannabinoid system seems to play a role with the receptors CB1 and CB2. Source: BOEDEFELD, Christian. Können Cannabinoide bei der Behandlung von Rosazea helfen?  17 Feb, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/koennen-cannabinoide-bei-der-behandlung-von-rosazea-helfen/ source photo: https://pixabay.com/cs/

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How does cannabidiol help against tension?

Countless reports and studies have confirmed the beneficial effects of cannabidiol, or CBD, for many ailments. And because of the experimental mood that people are developing when using extracts, crystals or oils that are now readily available online or in stores, more and more complaints are coming up on the list of diseases that CBD can help with. What are tensions and where do they come from?Hardly anyone will call tension a disease, and yet it is the pain and unpleasant sensations that can diminish the quality of life, and, above all, affect a large part of the people sooner or later.Almost everyone, regardless of whether they do physical work or have a desk job, is tense due to wrong or too little exercise, overuse, but mostly due to incorrect posture while sitting, at some point in life. Because of the frequency with which tensions due to malposition also occur without other physical overload, she was formerly called "secretary's disease". The musculoskeletal system is over-stimulated and causes discomfort. Usually the shoulders and the neck are affected, but the hyperacidity of the cells, which leads to the hardened muscles and ultimately to the tension, is possible in each one-sided loaded muscle. How does cannabinoid CBD generally work?Anyone who researches the effects of CBD will quickly have reason to hope for a positive influence of the cannabinoid on tension. Generally, cannabidiol is known to have a relaxing effect on the body, and this may not be wrong in the case of muscle hardening. The circulation-enhancing effect should also improve the oxygenation in the tense muscles and thereby additionally relax them. And also as a painkiller CBD can be used here. Since the symptoms often lead to the patient unconsciously moving into so-called postural conditions, which aggravate the tensions and can trigger other illnesses, the analgesic function is of short-term as well as long-term importance, because alleviating acute symptoms such as headache Dizziness also creates a situation that will allow the patient to relax first.Which is the right kind of application?CBD can therefore be versatile against tension. And just as versatile are the ways in which CBD can be administered. Of course, oils, extracts or crystals for internal use are a good base for supporting healing. But Cannabidiol can also be excellently applied and massaged directly onto the affected part of the body. Is CBD sufficient as treatment alone?If the patient has severe and permanent pain from the tensions that affect his quality of life lasting, then the way to the doctor is the only correct. For really extreme tensions, injecting a painkiller directly into the body part may be the way for some. However, whether for these serious cases or for all people suffering from tension, CBD can support and accelerate the healing process in a variety of ways. Of course, patients should take into account that the causes of tension must also be eliminated, for example the malpositions. With its wide range of effects and applications from the acute to the chronic area, CBD can be integrated into the everyday life of people with tension free from unwanted side effects. Such a lot of positive effects and easy availability make CBD a valuable tool that you might want to give a place in the medicine cabinet. Source: KLAUS GLASMANN, Dieter Klaus Glasmann. Wie hilft Cannabidiol gegen Verspannungen? 19 Dec, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/wie-hilft-cannabidiol-gegen-verspannungen/ source photo: https://pixabay.com/cs/

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CBD - protective effect for the cardiovascular system

First place among the leading causes of death worldwide is cardiovascular disease, which is due to inflammation of the cardiovascular system. A good means of prevention could be the cannabinoid CBD (cannabidiol) known for its anti-inflammatory effect. Animal experiments also suggest that CBD can also help to recover better and faster from the consequences of a heart attack or stroke. Although one can counteract such diseases through a healthy lifestyle, unfortunately, most people only become aware of the dangers when the first symptoms have already appeared. Often, however, it is no longer enough to "just" get rid of bad habits, but further measures will be necessary. All by itself or in combination with conventional medical treatments, cannabis or cannabidiol could be a good way to strengthen and protect the cardiovascular system. The heart and its associated network of blood vessels, known as the cardiovascular system, acts as a body-wide transport system for our blood. If this system has an error or corruption, it can have serious consequences. On the one hand, this can trigger a heart attack, which leads to the death of one area of ​​the heart muscle (myocardium), on the other hand, a stroke can be the result, which means that the brain cells can no longer be adequately supplied. Often, such a disease can be attributed to inflammation in the organism. And this is the starting point for treatment with CBD, whose anti-inflammatory properties have been proven in various scientific studies. In one of these studies, created by an international team of researchers from Israel, Taiwan, Hungary, the USA and Switzerland, animal experiments have shown that cannabidiol can help to heal myocarditis. CD3 and CD4 lymphocyte counts decreased significantly in rats treated with CBD on a sustained basis. This could counteract an expansion of heart disease, giving the damaged tissue after a heart attack the opportunity to recover faster and more sustainably. In another study, in which rabbits were treated with CBD after a heart attack, a positive influence on the healing process could be confirmed, unlike in the placebo group. But also to prevent such a cardiovascular disease, the use of CBD may be useful to eliminate potential risk factors. In addition to the well-known sedative and stress-reducing effect, positive effects on blood pressure, metabolism and obesity could also be observed in further studies. Furthermore, American scientists have recently completed an evaluation of 24 studies conducted between 1975 and 2017 on the "link between cannabis and cardiovascular disease" and concluded that there was no clear evidence of a link between cannabis use and the triggering of heart (muscle) infarctions or strokes. In addition to the ones mentioned here, there are a lot of other studies that confirm the positive medical benefit of cannabidiol on cardiovascular disease. In addition to cannabidiol, cannabis also contains a variety of other cannabinoids. The best-known and most researched of these is probably tetrahydrocannabinol (THC). THC is often warned that it is harmful to the heart and the rest of the cardiovascular system. As so often, however, it depends on the dosage. THC, just like CBD, can activate the CB2 receptors, which are located above all in the immune cells of our body. Therefore, it also has the ability to reduce inflammation and the level of free radicals that may otherwise increase the risk of strokes or heart attacks. THC, however, also docks to the CB1 receptors in the body. These are found, inter alia, throughout the cardiovascular system, where they are everywhere from the blood vessels to the heart muscle to the nerves in the brain responsible for heart rate control. On the one hand, activation of these receptors may be positive, e.g. On the other hand, however, with high doses of THC, the interaction between the cannabinoid and the CB1 receptors may superimpose the effect of the CB2 receptors and produce the exact opposite effect. In addition, activation of the CB1 receptors may contribute to the formation of deposits of substances such as cholesterol and fat in the blood vessels. Should one therefore be faced with the decision to choose a variety that is as supportive as possible to the protection and function of the cardiovascular system, then it might be worth taking a look at the low THC / high CBD category. Source: KRONBERGER, Ferdinand. CBD – schützende Wirkung für das Herz-Kreislauf-System. 1 [online]. 19 Dec, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-schuetzende-wirkung-fuer-das-herz-kreislauf-system/ source photo: https://pixabay.com/cs/ 

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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CBD gegen Hautkrankheiten - nÃttzt Cannabidiol der Hautgesundheit?

CBD and skin diseases: Does cannabidiol help with atopic dermatitis?Atopic dermatitis is considered a particularly onerous skin disease, as it often occurs already in infancy. The face and scalp of the baby are already covered shortly after birth with the characteristic milk scab; on the insides of knees and elbows arise so-called flexion eczema. The scaly and weeping eczema on the skin is accompanied by tormenting itching, which robs those affected of their sleep and makes any skin contact - even wearing clothes - painful. In adults, the symptoms usually culminate in spurts, the triggers of which are often not clearly identified. Atopic dermatitis flare-ups occur when the affected immune system over-reacts to internal or external irritants. The triggers can be both specific foods and stressful situations. The idea of ​​using cannabidiol for the treatment of atopic dermatitis is obvious because the nerve fibers of the skin possess cannabinoid receptors and endocannabinoids have been shown to be involved in the regulation of the immune system. Cannabinoid ointment relieves eczema symptomsThe first attempt to treat atopic dermatitis patients with cannabinoids was undertaken by Munich scientists in 2008. They administered 2456 participants a skin cream with the cannabinoid N-palmitoylethanolamine (PEA). As a result, 60 percent of the subjects were able to reduce itching, redness, and flaking areas of the skin. More than half of the atopic dermatitis patients were also able to do without cortisone medication.  ObCBD as cannabinoid could achieve comparable effects in people with neurodermatitis, has not yet been investigated in clinical trials. Its anti-inflammatory effect, which can suppress excessive immune system responses, has been confirmed in animal studies. On the basis of previous findings, scientists call CBD and cannabidiol containing preparations as a possible future remedy for skin diseases such as eczema, but also acne, contact allergies, psoriasis and itching.  CBD for common skin diseases: Does cannabidiol have an effect on acne?To call acne a skin disease, many people consider exaggerated. In fact, statistically, around 75 to 90 percent of teenagers worldwide suffer from acne-like skin changes. In about 10 percent of those affected, however, this symptom persists in adulthood and causes physical and mental discomfort. In the process, acne does not result from unhealthy diets or poor hygiene - in fact, the pimples and pustules are the result of dysregulation of certain skin cells: both the sebaceous glands and the horn-forming cells appear overactive here. While sebum is increasingly produced, the horny cells close the exits of the sebaceous follicles. The skin fat does not drain, but offers bacteria such as the Propionibacterium acnes a breeding ground and it comes to inflammation. CBD regulates the activity of certain skin cellsAt least, laboratory tests suggest that CBD, through the activation of the type 4 vanilloid receptor, reduces both the productivity of the sebaceous cells, as well as the horn-forming activity through other mechanisms Cells (keratinocytes) inhibits. Both effects could have a positive effect on the symptoms of acne. Also in psoriasis, which is also characterized by an overactivity of the horn-forming cells, the regulative action of CBD could possibly be beneficial. However, clinical studies that would confirm a positive effect on acne or psoriasis are still missing at this time. Cannabidiol for severe skin diseasesHowever, concrete case reports on the effect of CBD on skin diseases are available elsewhere: Epidermolysis bullosa is a serious inherited skin disease that can even lead to death. Those affected suffer from painful wounds, scars and adhesions that limit the range of motion. The symptom picture is sometimes called "butterfly skin" because the epidermis of the patient seems to be as sensitive as the wing of a butterfly. Could CBD be useful here? An indication can be found in the medical literature. Here is the report of 3 epidermolysis bullosa patients who used CBD oil on the skin. All reported better wound healing, less blistering, and reduced pain from the therapy. One of the patients was even able to do without the opioid painkillers he usually took for the symptoms.  CBD on the skin - does it work in the entire organism?If you use CBD oil or cream, you should be aware that the ingredients are not only local, but also absorbed into the bloodstream. Cannabidiol even reaches the blood 10 times more effectively via the so-called transdermal passage than the psychoactive ingredient THC.  CBD oil or cream - what is best for the application on the skin?While CBD oil is dripped under the tongue, taking cannabidiol through the oral mucosa into the bloodstream, CBD cream and CBD balm develop their effect directly on the skin. Quality products are characterized by the fact that they are based on a full-spectrum extract. In addition to CBD, this contains other cannabinoids, flavonoids and terpenes, and in this way favors the so-called Entourage effect. Scientists assume that different cannabinoids increase each other's beneficial effects. High-quality CBD creams also contain no artificial preservatives, dyes and fragrances. Only vitamin E, which acts as an effective antioxidant, prevents the cream from spoiling on contact with oxygen. Natural oils and vegetable fats such as shea butter or mango butter additionally help the skin to retain its own moisture and make it supple. Source: CBD gegen Hautkrankheiten – nützt Cannabidiol der Hautgesundheit? 1 [online]. 21 Aug,2019, Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-gegen-hautkrankheiten source photo: https://pixabay.com/cs/ 

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How does CBD affect the irritable bowel?

The so-called irritable bowel syndrome (RDS) is actually no exact name of a specific disease. Rather, this term collects a number of inflammatory bowel diseases of different causes and manifestations. There are variants such as Crohn's disease, which actually go beyond the symptoms of RDS, because in Crohn's disease, the small intestine is affected, while the classic RDS occurs only in the colon. Nearly half of all cases in which a patient is referred to the gastroenterologist (gastrointestinal specialist) are related to the widespread disease. How is the irritable bowel syndrome diagnosed?Unequivocally diagnosing irritable bowel syndrome is a complicated affair. Often the symptoms can also be associated with other diseases, therefore, confusion often happen. This can often be avoided by having a good and detailed history that the doctor should really take time to do. It includes information about the period of the disease, About changes in the toilet habits and the like, which can lead the doctor on the right track. If the suspected diagnosis is in the first place, various blood tests, colonoscopy and other imaging techniques, as well as the examination of a stool sample are necessary to ensure a reliable diagnosis. How is irritable bowel syndrome treated?Since the irritable bowel is a widespread widespread disease, there are a lot of funds available, with which one can provide relief. For mild symptoms, a diet that dispenses with a range of short-chain carbohydrates and polyhydric alcohols can help. Depending on whether the condition is more likely to be constipated or diarrhea, a laxative or anti-drainage drug may be administered. In general, the increased intake of fiber is recommended. Psyllium husks and barley have proven to be particularly useful. Camomile, myrrh and coffee charcoal are also considered to be very effective in relieving symptoms. To restore a healthy intestinal flora, the use of so-called probiotics (bacterial strains) was helpful. Although the pharmaceutical industry has also developed some products for the treatment of irritable bowel syndrome, these are often associated with side effects that do not justify their use for many people. The natural alternatives are clearly to be preferred here. What Can CBD Do For Irritable Bowel Syndrome?In 2004, the neurologist and former president of the International Association for Cannabis as Medicine, Ethan Russo, linked irritable bowel syndrome to the endocannabinoid system or deficits in a publication. Russo points to studies showing that malfunctions in the endocannabinoid system can cause inflammatory bowel disease. Consequently, cannabis can effectively remedy this situation. At first, it was claimed that cannabidiol (CBD) alone was not enough, but THC was also needed. This claim has since been revised, and it has been found that CBD is an important agent in the treatment of inflammatory bowel disease, which can both fight inflammation and regulate the function of glial cells (cells in the nervous tissue, but which are not neurons) , The immunomodulatory properties of CBD have been shown to positively affect disease progression and symptoms in studies. CBD can be of great help even in the severe Crohn's disease, and most recent research has yielded very promising results, making CBD a real hope for many gastrointestinal patients. Source: GLASMANN, Dieter Klaus. Wie wirkt CBD auf den Reizdarm?, 3 Oct, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/wie-wirkt-cbd-auf-den-reizdarm/ source photo: https://pixabay.com/cs/

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