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CBD - protective effect for the cardiovascular system

First place among the leading causes of death worldwide is cardiovascular disease, which is due to inflammation of the cardiovascular system. A good means of prevention could be the cannabinoid CBD (cannabidiol) known for its anti-inflammatory effect. Animal experiments also suggest that CBD can also help to recover better and faster from the consequences of a heart attack or stroke. Although one can counteract such diseases through a healthy lifestyle, unfortunately, most people only become aware of the dangers when the first symptoms have already appeared. Often, however, it is no longer enough to "just" get rid of bad habits, but further measures will be necessary. All by itself or in combination with conventional medical treatments, cannabis or cannabidiol could be a good way to strengthen and protect the cardiovascular system. The heart and its associated network of blood vessels, known as the cardiovascular system, acts as a body-wide transport system for our blood. If this system has an error or corruption, it can have serious consequences. On the one hand, this can trigger a heart attack, which leads to the death of one area of ​​the heart muscle (myocardium), on the other hand, a stroke can be the result, which means that the brain cells can no longer be adequately supplied. Often, such a disease can be attributed to inflammation in the organism. And this is the starting point for treatment with CBD, whose anti-inflammatory properties have been proven in various scientific studies. In one of these studies, created by an international team of researchers from Israel, Taiwan, Hungary, the USA and Switzerland, animal experiments have shown that cannabidiol can help to heal myocarditis. CD3 and CD4 lymphocyte counts decreased significantly in rats treated with CBD on a sustained basis. This could counteract an expansion of heart disease, giving the damaged tissue after a heart attack the opportunity to recover faster and more sustainably. In another study, in which rabbits were treated with CBD after a heart attack, a positive influence on the healing process could be confirmed, unlike in the placebo group. But also to prevent such a cardiovascular disease, the use of CBD may be useful to eliminate potential risk factors. In addition to the well-known sedative and stress-reducing effect, positive effects on blood pressure, metabolism and obesity could also be observed in further studies. Furthermore, American scientists have recently completed an evaluation of 24 studies conducted between 1975 and 2017 on the "link between cannabis and cardiovascular disease" and concluded that there was no clear evidence of a link between cannabis use and the triggering of heart (muscle) infarctions or strokes. In addition to the ones mentioned here, there are a lot of other studies that confirm the positive medical benefit of cannabidiol on cardiovascular disease. In addition to cannabidiol, cannabis also contains a variety of other cannabinoids. The best-known and most researched of these is probably tetrahydrocannabinol (THC). THC is often warned that it is harmful to the heart and the rest of the cardiovascular system. As so often, however, it depends on the dosage. THC, just like CBD, can activate the CB2 receptors, which are located above all in the immune cells of our body. Therefore, it also has the ability to reduce inflammation and the level of free radicals that may otherwise increase the risk of strokes or heart attacks. THC, however, also docks to the CB1 receptors in the body. These are found, inter alia, throughout the cardiovascular system, where they are everywhere from the blood vessels to the heart muscle to the nerves in the brain responsible for heart rate control. On the one hand, activation of these receptors may be positive, e.g. On the other hand, however, with high doses of THC, the interaction between the cannabinoid and the CB1 receptors may superimpose the effect of the CB2 receptors and produce the exact opposite effect. In addition, activation of the CB1 receptors may contribute to the formation of deposits of substances such as cholesterol and fat in the blood vessels. Should one therefore be faced with the decision to choose a variety that is as supportive as possible to the protection and function of the cardiovascular system, then it might be worth taking a look at the low THC / high CBD category. Source: KRONBERGER, Ferdinand. CBD – schützende Wirkung für das Herz-Kreislauf-System. 1 [online]. 19 Dec, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-schuetzende-wirkung-fuer-das-herz-kreislauf-system/ source photo: https://pixabay.com/cs/ 

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GPR55 - The new cannabinoid receptor

His discovery is actually almost 20 years back, but only today he gains attention and importance. Meanwhile, the receptor called GPR55 also becomes CB3, the third relevant cannabinoid receptor in the human endogenous cannabinoid system. Endocannabinoid systemUntil quite some time ago, we knew that THC, which resembles the endogenous cannabinoid anandamide, binds to receptors in the brain, and as a result has an effect on our body. In the meantime, we know about the endocannabinoid system, which allows humans to use endocannabinoids, which the body itself produces, to perform a variety of health and immune functions. This system also harnesses the cannabinoids that we infuse from the outside by taking cannabis. The CB1 receptorSo far, two receptors are known, which are simply described with CB1 and CB2. The CB1 receptor can bind to both THC and CBD. Because they "compete" for the CB1 receptor during the effect of cannabis in the body, and CBD is not known to be psychoactive, CBD cushions the "high" effect of THC. These receptors are found mainly in the central nervous system, thus affecting the sensation of pain and also the motor skills, but also emotions, memory and appetite. The CB2 receptorThe CB2 receptor is found in organs of the immune system, mast cells and lymphocytes. While cannabis is believed to affect the immune system, the assumption that CBD interacts directly with the CB2 receptor is outdated. Rather, it seems that the cannabinoids cause the body to use more of its own endocannabinoids. CBD, GPR55 and cancerThe receptor GPR55, which was discovered in 1999 and can be found in the brain and peripheral nervous system, seems to be able to work with many different cannabinoids. It has differences to CB1 and CB2, but is 13 percent identical in construction to CB1 and 14.4 percent to CB2. One might now assume that cannabidiol (CBD) might dock specifically to the CB3 receptor. However, this does not seem to be the case, CBD even blocks the receptor. But this does not mean that CBD is useless for the receptor or for the medical influence of it, on the contrary. GPR55 signaling is said to be associated with the development or progression of cancer. Thus, the use of CBD targeted to block the signal transmission inhibit the growth of some tumors. CBD, GPR55 and epilepsyAlthough the diseases do not resemble each other, the apparent effect of CBD in epilepsy can be explained by the same principle as cancer. Among other things, GPR55 also occur in the hippocampus, the area of ​​the brain in which spatial orientation and long-term memory are located. CBD has shown significant improvements in the intensity, quantity, and duration of seizures in some forms of epilepsy. CBD, GPR55 and irritable bowel syndromeCBD also has a positive influence on this intestinal disease. Fast and permanent improvement of well-being and relief of symptoms is reported. And again, this is associated with inhibition of signal transduction from GPR55. But in irritable bowel syndrome, it is also the anti-inflammatory properties of CBD, the help in the most chronic stomach and intestinal disorders. Only the beginningMany details about the CB3 receptor and the role it plays in our health are still unclear. But this concerns the whole endogenous cannabinoid system and its receptors, the cannabinoids, whether endogenous or supplied, and the terpenes and their many interactions and possible interactions with our bodies. But with every new insight, the accuracy with which we can use the properties of the cannabis plant for our health increases. Source: KLAUS GLASMANN, Dieter. GPR55 – Der neue Cannabinoid-Rezeptor. 1 [online] 30 Aug, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/gpr55-der-neue-cannabinoid-rezeptor/ source photo: https://pixabay.com/cs/

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CBD against circulatory disorders

A number of problems an organism can develop in the course of a lifetime are associated with impaired blood flow and inadequate oxygenation of body parts and organs. These include minor cramping of the muscles in the extremities as well as stroke, in which areas of the brain are underserved and long-term brain damage can remain. Disturbed blood flowBlood flows through every part of our body, only dead cells such as hair and fingernails are not traversed by vessels that transport all imaginable nutrients to the smallest angles. Since our diet and our lifestyle also pollutants, fats and the like can enter our bloodstream, the blood flow in many parts of the body can be disturbed by deposits. In addition, with aging, the flexibility of our veins subsides, but also environmental influences and harmful habits like smoking can constrict the vessels. Small tingling and big risksRegardless of the causes of a circulatory disorder or where it is located, it is commonly referred to as ischemia (low blood flow). In the arms or legs show slight circulatory problems, in which the foot or leg begin to tingle, also cramps of the muscles are possible. The death of parts of the body, for example the well-known smoker's leg, can also be the result of a circulatory disorder. In even worse cases, ischemia threatens the heart or brain, and can lead to strokes and heart attacks, and thus become life threatening. Canes for ischemia?The fact that smoking is harmful, narrows the blood vessels and takes away their flexibility, many potheads regret, after all, it remains to this day, the most popular form of cannabis. On the other hand, the example of glaucoma, which is related to the intraocular pressure and blood flow of the eye, has long been proven that cannabis can improve hemodynamics, ie blood flow. Cannabidiol (CBD) has several effects on blood circulation. Both the soothing, relaxing effect that lowers blood pressure and the vasodilation effect may be important here. In the genesis of ischemic strokes, remarkable results have already been achieved through the use of CBD. In admittedly unsightly tests on rats, CBD has been able to minimize brain damage by 17 percent. CBD inhibits arteriosclerosisArterial calcification and deposits in the blood vessels are one of the main causes of ischemic diseases. Here cannabidiol is medically particularly interesting. Research from Switzerland now assumes that CBD can slow down the progression of arteriosclerosis caused by high blood sugar levels. This prevents ischemic diseases or influences existing ones positively. Since smoking cannabis (especially mixed with tobacco), even if it is a high CBD variety, is rather counterproductive, CBD oils and extracts, which are available as a dietary supplement, are suitable. What to look forOf course, if you suffer from a serious circulatory disorder, going to the doctor is not only compulsory but also the only sensible thing to do. The risks are too big here to carry out self-experiments. But of course you can certainly discuss the use of CBD products with the doctor. When choosing the product one should always keep in mind the entourage effect, according to which the effects of cannabinoids and terpenes favor and enhance one another. This also makes sense for ischemic symptoms, as the cannabinoid cannabigerol (CBG), for example, has an effect on blood pressure. It is therefore advisable to always use CBD products with the full spectrum of cannabis, ie full-spectrum CBD oils or full extracts. Manufacturers who work with rich raw materials and deliver quality will surely mark this on their labels. If only CBD is indicated on the packaging of an oil, and the oil may still be colorless, it can not necessarily be assumed that it contains an extract of all the active ingredients of the hemp plant. Source: KLAUS GLASMANN, Dieter. CBD gegen Durchblutungsstörungen. 1 [online], 30 Sep, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-gegen-durchblutungsstoerungen/ source photo: https://pixabay.com/cs/

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CBD for the treatment of brain tumors

Recently, new study results were published in a research project at St. George's University of London in collaboration with the Dove Clinic. Dr. Julian Kenyon, dr. Wai Liu and Angus Dalleish demonstrate a reduction in the size of ependymomas, both in childhood (pediatric) and adults, through the medical use of cannabidiol. Ependymomas are defined as certain types of tumors that make up about 5 to 10% of all brain tumors (gliomas). In children, they are the third most common cancer of the central nervous system. As ependymomas of the cerebrum, they appear at any age, while in the posterior fossa they occur mainly in childhood, and in the spinal cord more in adulthood. Strong decline of tumor cellsA number of case studies of cancer patients were examined, including brain tumor patients. These were administered pharmaceutical grade quality oil based on a synthetic form of CBD. Data were collected and evaluated over four years as part of the treatment of 119 cancer patients at the Dove Clinic. In 92 percent of cases, CBD medication was seen to improve upon repeated brain scans. Either in the form of a reduction of the tumor cells that cause metastases (circulating tumor cells), or in the form of a reduction in tumor size. However, in brain tumors of adult patients who had lost their size due to CBD, the tumor continued to grow after discontinuation of cannabidiol, which then resumed treatment with the drug. According to the researchers, this study should not be entitled to comprehensive findings. It should rather be an impetus for further investigations, which are undoubtedly justified by the results. If convincing evidence is provided, pharmaceutical grade CBD oil can be made more widely available and cheaper, researchers hope. In the research on cannabis as a medicine, and on the therapeutic use of CBD in particular, there is still a lot of work to be done to understand which type of CBD oil is most effective and in which dose it can best produce the best effect , The many synergy effects with other treatment measures need to be further explored, as well as the effects of diet and lifestyle habits. Increased chances of survivalIn another study conducted by British biopharmaceutical company GW Pharmaceuticals, cannabis (1: 1) agents were administered to one group of brain tumor patients, one to another. Both were given in addition to the respective standard therapy in patients with particularly poor survival prognoses (the patients had relapsing glioblastoma multiforme, called GBM for short). While almost half of the patients in the placebo group did not survive the following year (47 percent), the drug group had a survival rate of 83 percent over the same period. On average, one patient survived the drug group for 550 days and one member of the placebo group only 369. No "do-it-yourself" medicineThe cautionary note, which I already pronounce for less severe illnesses, is all the more important in the case of cancer and similarly serious illnesses. If you have a bad illness, first of all you should consult the specialist for his diagnosis. In the case of illness, it should be refrained from experimenting on its own with any CBD oils around. The study's leaders expressly point out the differences in the qualities of various oils, so it is by no means advisable to self-medicate without consultation with the doctor. Source: GLASMANN, Dieter Klaus. CBD zur Behandlung von Hirntumoren. 1 [online]. 5 Oct, 2018]. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-zur-behandlung-von-hirntumoren/ source photo: https://pixabay.com/cs/

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What are phytocannabinoids?

Phytocannabinoids are cannabinoids produced by plants. Mainly these agents are found in cannabis plants. However, there are also indications that phytocannabinoids are also formed by other plants. Just like endocannabinoids, they activate our cannabinoid receptors. The plant genus Cannabis Sativa contains more than 100 phytocannabinoids, which belong to the group of so-called terpephenols. The best-known phytocannabinoids include THC and CBD. This group of substances has not been discovered in any other plant. Phytocannabinoids activate the CB1 and CB2 receptors of the endocannabinoid system and thereby produce their characteristic effect. The active ingredients are agonists (that is, the occupation of a receptor activates a process) or antagonists (the activation inhibits a cell process) of the CB1 or CB2 receptors. Phytocannabinoids have a high potential for use as medicine. The counterpart to this are endogenous cannabinoids. They are produced by our bodies themselves and are involved in metabolic processes and other important tasks. The two most important endocannabinoids include anandamide, 2-arachidonylglycerol (2-AG). Our endogenous cannabinoid system consists of countless receptors distributed throughout our body. CB1 receptors are mainly found in the brain, while the immune system and central nervous system are mostly CB2 receptors. It is believed that our endocannabinoid system is responsible for maintaining the balance in the body and plays an important role in our well-being. The most important phytocannabinoidsTetrahydrocannabidiol (THC)THC is probably the best-known phytocannabinoid and provides the psychoactive effect of cannabis use. This is precisely the reason why cannabis is considered illegal in many parts of the world. It can affect mood and appetite and is known for its anti-inflammatory effects. Cannabidiol (CBD)At least as well known is CBD. Cannabidiol is valued above all for its therapeutic properties, which as a dietary supplement is an ideal enrichment to the daily diet. It is not psychoactive and is legally available in many countries in the form of oils or creams. Cannabigerol (CBG)CBG is considered the precursor of most other phytocannabinoids. The cannabinoid is thought to have a variety of therapeutic uses, with studies suggesting that it is even more effective than CBD in certain conditions. Over time, enzymes from the plant convert cannabigerol into other cannabinoids, which is why the level in the "finished" plant is relatively low. Cannabidivarin (CBDV)CBDV is another non-psychoactive cannabinoid. The chemical structure is very similar to CBD and the use of cannabidivarin in the treatment of epilepsy is currently under investigation. Cannabichromene (CBC)CBC is a cannabinoid that could be of interest for its medicinal properties. Studies give an idea of ​​how CBC produces antigens in tumor cells by activating CB2 receptors that are cleared by immune cells. In addition, the use of cannabichromene in Alzheimer's therapy is discussed. Of course, these are just a small selection of the most popular phytocannabinoids. Currently, more than 100 phytocannabinoids of the cannabis plant are known, which unfold their unique effect, the entourage effect. Phytocannabinoids play an important role in our endocannabinoid system. Although some progress has already been made in research, more efforts are needed to unlock the full potential of these compounds. Source: BOEDEFELD, Christian. Was sind Phytocannabinoide? 1 [online]. 8 Nov, 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/was-sind-phytocannabinoide/ source photo: https://pixabay.com/cs/

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