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CBD as antibiotic - does cannabidiol help against bacterial infections?

inflammation or respiratory tract infection - almost every patient had to take antibiotics once in a lifetime to get rid of the condition. However, with growing coverage of resistant bacteria, fewer and fewer people trust the chemical drugs without reservation; many are looking for alternatives. If natural products such as e.g. CBD oil actually help here? What causes an antibiotic?The term antibiotics is composed of the Greek terms "anti" and "bios" and means something like: against life. Originally it referred to as bacteria-expelled metabolites that inhibit the growth of other microorganisms in their environment. In modern medicine, all partially and fully synthetic substances that kill bacteria and inhibit their multiplication as an antibiotic apply. Problems with antibiotics - do natural ingredients have benefits?The biggest problem with using synthetic antibiotics is that certain strains of bacteria become insensitive to them over time and a drug loses its effect. Not only the frequent prescription of antibiotics promotes the resistance, but also their industrial use. In the animal fattening producers want to prevent infectious diseases by large-scale Antibiotikagaben, but thereby risk residues in their products. These in turn can lead to the formation of resistant bacterial strains in the consumer. Researchers are increasingly testing natural antibacterial substances such as oregano oil, garlic extracts or honey as part of their search for drug candidates for resistant bacteria. Here is the thesis that natural substances are too complex for bacteria to resist. In the course of this, CBD will also be interesting for research: Does CBD have antibiotic properties?Researchers already demonstrated that cannabidiol has an antibacterial effect on streptococci and staphylococci in the 1970s. [1] At that time it was concluded from the results that this effect applies only to gram-positive bacteria, whereas gram-negative bacteria are resistant to CBD. Other data was presented by the research team led by Mark Blaskovich at this year's American Society for Microbiology conference, ASM Microbe in San Francisco. According to Blaskovich, the previously unpublished study shows how CBD eliminated bacterial strains that are already resistant to common antibiotics. In addition, no resistance to cannabidiol developed in the bacteria even after exposure to the cannabinoid for about 20 days. According to the scientists, CBD demonstrated efficacy against MRSA, the methicillin-resistant Staphylococcus aureus, which is responsible for serious hospital infections. Lead chemist Mark Blaskovich, in an interview with Newsweek, explained the current state of knowledge on CBD as an antibiotic: "We do not yet know how it works, but it could have a unique mechanism if confirmed to work against antibiotic-resistant bacteria." Can CBD increase the effects of antibiotics?In a study published in 2019, researchers demonstrated in a study published in 2019 how CBD could influence resistant bacteria: experts call materials that release bacteria via their outer sheath as outer membrane vesicles. They primarily serve the communication of the bacteria with each other, but also the exchange of DNA, the formation of a biofilm and the release of defense enzymes against immune cells. Cannabidiol can effectively inhibit these membrane vesicles, particularly in the bacterium E. coli. As a result, various antibiotics in combination with CBD were more effective against certain Gram-negative bacteria. According to the authors, CBD may help reduce resistance to antibiotics.  Source: CBD als Antibiotikum – hilft Cannabidiol gegen bakterielle Infektionen? 1 [online]. 23 Oct, 2018. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-als-antibiotikum source photo: https://pixabay.com/cs/

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CBD gegen Hautkrankheiten - nÃttzt Cannabidiol der Hautgesundheit?

CBD and skin diseases: Does cannabidiol help with atopic dermatitis?Atopic dermatitis is considered a particularly onerous skin disease, as it often occurs already in infancy. The face and scalp of the baby are already covered shortly after birth with the characteristic milk scab; on the insides of knees and elbows arise so-called flexion eczema. The scaly and weeping eczema on the skin is accompanied by tormenting itching, which robs those affected of their sleep and makes any skin contact - even wearing clothes - painful. In adults, the symptoms usually culminate in spurts, the triggers of which are often not clearly identified. Atopic dermatitis flare-ups occur when the affected immune system over-reacts to internal or external irritants. The triggers can be both specific foods and stressful situations. The idea of ​​using cannabidiol for the treatment of atopic dermatitis is obvious because the nerve fibers of the skin possess cannabinoid receptors and endocannabinoids have been shown to be involved in the regulation of the immune system. Cannabinoid ointment relieves eczema symptomsThe first attempt to treat atopic dermatitis patients with cannabinoids was undertaken by Munich scientists in 2008. They administered 2456 participants a skin cream with the cannabinoid N-palmitoylethanolamine (PEA). As a result, 60 percent of the subjects were able to reduce itching, redness, and flaking areas of the skin. More than half of the atopic dermatitis patients were also able to do without cortisone medication.  ObCBD as cannabinoid could achieve comparable effects in people with neurodermatitis, has not yet been investigated in clinical trials. Its anti-inflammatory effect, which can suppress excessive immune system responses, has been confirmed in animal studies. On the basis of previous findings, scientists call CBD and cannabidiol containing preparations as a possible future remedy for skin diseases such as eczema, but also acne, contact allergies, psoriasis and itching.  CBD for common skin diseases: Does cannabidiol have an effect on acne?To call acne a skin disease, many people consider exaggerated. In fact, statistically, around 75 to 90 percent of teenagers worldwide suffer from acne-like skin changes. In about 10 percent of those affected, however, this symptom persists in adulthood and causes physical and mental discomfort. In the process, acne does not result from unhealthy diets or poor hygiene - in fact, the pimples and pustules are the result of dysregulation of certain skin cells: both the sebaceous glands and the horn-forming cells appear overactive here. While sebum is increasingly produced, the horny cells close the exits of the sebaceous follicles. The skin fat does not drain, but offers bacteria such as the Propionibacterium acnes a breeding ground and it comes to inflammation. CBD regulates the activity of certain skin cellsAt least, laboratory tests suggest that CBD, through the activation of the type 4 vanilloid receptor, reduces both the productivity of the sebaceous cells, as well as the horn-forming activity through other mechanisms Cells (keratinocytes) inhibits. Both effects could have a positive effect on the symptoms of acne. Also in psoriasis, which is also characterized by an overactivity of the horn-forming cells, the regulative action of CBD could possibly be beneficial. However, clinical studies that would confirm a positive effect on acne or psoriasis are still missing at this time. Cannabidiol for severe skin diseasesHowever, concrete case reports on the effect of CBD on skin diseases are available elsewhere: Epidermolysis bullosa is a serious inherited skin disease that can even lead to death. Those affected suffer from painful wounds, scars and adhesions that limit the range of motion. The symptom picture is sometimes called "butterfly skin" because the epidermis of the patient seems to be as sensitive as the wing of a butterfly. Could CBD be useful here? An indication can be found in the medical literature. Here is the report of 3 epidermolysis bullosa patients who used CBD oil on the skin. All reported better wound healing, less blistering, and reduced pain from the therapy. One of the patients was even able to do without the opioid painkillers he usually took for the symptoms.  CBD on the skin - does it work in the entire organism?If you use CBD oil or cream, you should be aware that the ingredients are not only local, but also absorbed into the bloodstream. Cannabidiol even reaches the blood 10 times more effectively via the so-called transdermal passage than the psychoactive ingredient THC.  CBD oil or cream - what is best for the application on the skin?While CBD oil is dripped under the tongue, taking cannabidiol through the oral mucosa into the bloodstream, CBD cream and CBD balm develop their effect directly on the skin. Quality products are characterized by the fact that they are based on a full-spectrum extract. In addition to CBD, this contains other cannabinoids, flavonoids and terpenes, and in this way favors the so-called Entourage effect. Scientists assume that different cannabinoids increase each other's beneficial effects. High-quality CBD creams also contain no artificial preservatives, dyes and fragrances. Only vitamin E, which acts as an effective antioxidant, prevents the cream from spoiling on contact with oxygen. Natural oils and vegetable fats such as shea butter or mango butter additionally help the skin to retain its own moisture and make it supple. Source: CBD gegen Hautkrankheiten – nützt Cannabidiol der Hautgesundheit? 1 [online]. 21 Aug,2019, Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-gegen-hautkrankheiten source photo: https://pixabay.com/cs/ 

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